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Molecular Markes of Fibrosis of Endometriosis and Their Use in Predicting Disease Severity
Sponsor: General University Hospital, Prague
Summary
The primary aim of the project is to analyse gene expression in individual types of ectopic endometrium (ovarian endometriosis, peritoneal endometriosis, deep infiltrating endometriosis) and compare it with gene expression in eutopic endometrium. The analysis focuses on the identification of genes with significantly increased expression in each type of ectopic endometrium and comparison of their expression with the degree of disease, ovarian reserve and clinical manifestations of the disease (pain, infertility).
Official title: Molecular Markes of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2023-04-01
Completion Date
2026-12-31
Last Updated
2023-08-31
Healthy Volunteers
No
Interventions
Molecular markes of fibrosis of single types of endometriosis and their use in predicting disease severity
The aim of the study is to analyze molecular markers of fibrosis in female patients with endometriosis vs. without endometriosis. These features will be compared for their clinical status and progression of the disease before and after treatment. Identification and validation of these features appears to be a crucial step in predicting progression of the disease. Moreover, we would be able to modify follow-up and treatment management in high-risk patients for endometriosis.
Locations (1)
General University Hospital in Prague
Prague, Czechia