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An Efficacy, Safety, and Tolerability Study of Veligrotug (VRDN-001), in Participants With Chronic Thyroid Eye Disease (TED)
Sponsor: Viridian Therapeutics, Inc.
Summary
This is a clinical trial assessing the efficacy, safety, and tolerability of an investigational drug, veligrotug (VRDN-001), in participants with chronic thyroid eye disease (TED).
Official title: A Randomized, Double-masked, Placebo-controlled Safety, Tolerability, and Efficacy Study of VRDN-001, a Humanized Monoclonal Antibody Directed Against the IGF-1 Receptor, in Participants With Chronic Thyroid Eye Disease (TED)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
188
Start Date
2023-11-01
Completion Date
2025-07-25
Last Updated
2026-08-13
Healthy Volunteers
No
Conditions
Interventions
Veligrotug
5 IV Infusions of veligrotug 10 mg/kg
Placebo
5 IV Infusions of veligrotug matched placebo
Locations (57)
Advancing Research International, LLC
Los Angeles, California, United States
USC Roski Eye Institute
Los Angeles, California, United States
Amy Patel Jain, MD
Newport Beach, California, United States
Stanford Byers Eye Institute
Palo Alto, California, United States
Cockerham Eye Consultants, PC
San Diego, California, United States
Bascom Palmer Eye Institute - Ophthalmology - Miami
Miami, Florida, United States
Sarasota Retina Institute
Sarasota, Florida, United States
Northwestern University
Chicago, Illinois, United States
Family Eye Physicians, Ltd
Oak Lawn, Illinois, United States
Massachusetts Eye and Ear
Boston, Massachusetts, United States
Ophthalmic Consultants of Boston
Boston, Massachusetts, United States
Michigan State University, Department of Neurology
East Lansing, Michigan, United States
Kahana Oculoplastic and Orbital Surgery
Livonia, Michigan, United States
Washington University School of Medicine in St Louis - Ophthalmology
St Louis, Missouri, United States
Steven Leibowitz, MD.
Las Vegas, Nevada, United States
Rutgers - New Jersey Medical School
Newark, New Jersey, United States
The Center for Eye and Facial Plastic Surgery
Somerset, New Jersey, United States
Department of Ophthalmology, University of Pennsylvania
Philadelphia, Pennsylvania, United States
Wills Eye Hospital
Philadelphia, Pennsylvania, United States
Baylor College of Medicine (BCM) - Ophthalmology
Houston, Texas, United States
Neuro Eye Clinical Trials
Houston, Texas, United States
University of Vermont Medical Center
Burlington, Vermont, United States
Harborview Medical Center
Seattle, Washington, United States
North Shore Private Hospital
Saint Leonards, New South Wales, Australia
CHU Angers
Angers, France
CHU de Bordeaux - Hôpital Saint-André
Bordeaux, France
Centre Hospitalier Universitaire De Nantes - G. R. Laennec
Nantes, France
CH Nice
Nice, France
Charité - Universitätsmedizin Berlin KöR
Berlin, Germany
Universitätsklinikum Essen AöR
Essen, Germany
University Medical Center Freiburg
Freiburg im Breisgau, Germany
Universitätsmedizin Göttingen
Göttingen, Germany
Budapest Retina Intezet
Budapest, Hungary
Ganglion Orvosi Kozpont
Pécs, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont Szemeszeti Klinika
Pécs, Hungary
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, Poland
Oculomedica Sp. z o.o.
Bialystok, Poland
Optimum Profesorskie Centrum Okulistyki Sp. z o.o.
Gdansk, Poland
Centrum Medyczne Pulawska Sp. z o.o.
Piaseczno, Poland
Centrum Medyczne Piasta 47 sp. z o.o.
Wałbrzych, Poland
Complexo Hospitalario Universitario de Santiago-Hospital Médico-Cirúrxico de Conxo
A Coruña, Spain
Centro de Oftalmologia Barraquer (Barraquer Ophthalmology Centre)
Barcelona, Spain
Hospital La Arruzafa
Córdoba, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Universitario Virgen De La Macarena
Seville, Spain
Hospital Universitario Virgen del Rocio
Seville, Spain
Hospital Universitario Y Politécnico La Fe
Valencia, Spain
Hospital Unviersitario Miguel Servet
Zaragoza, Spain
Hacettepe Universitesi Tip Fakultesi
Ankara, Turkey (Türkiye)
Gazi University Medical Faculty Hospital
Ankara, Turkey (Türkiye)
Akdeniz University Medical Faculty Hospital
Antalya, Turkey (Türkiye)
Marmara University Faculty of Medicine
Istanbul, Turkey (Türkiye)
Moorfields Eye Hospital
London, United Kingdom
Imperial College Healthcare NHS Trust - Western eye Hospital
London, United Kingdom
St. Thomas' Hospital
London, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom