Clinical Research Directory

Inclusion Criteria: * Individuals ≥ 18 years of age. * A clinical diagnosis of type 1 diabetes for at least one year, as per the investigators' clinical judgment (confirmatory C-peptide and antibodies will not be required). * Minimum 3-month use of a commercial advanced AID system. * Time in range (3.9 to 10.0 mmol/L) \< 70% on their personal AID system in the 30 days prior to screening (with minimum 70% time spent in closed-loop mode). * Agreement to use a highly effective method of birth control for individuals of child-bearing age and active avoidance of pregnancy during the trial. Child-bearing potential refers to participants of the female sex post-menarche who have not reached menopause and who do not have a disclosed medical condition causing sterility (ex: hysterectomy). Post-menopausal state refers to the absence of menses for 12 months without any alternative cause. Exclusion Criteria: * Current or ≤ 2 week use of any anti-hyperglycemic agent other than insulin (such as SGTL2i). * Current or ≤ 1 month use of Glucagon-like Peptide 1 (GLP1)-Receptor Agonists. * Current or ≤ 1 month use of supraphysiological doses of oral or intravenous glucocorticoids. * Planned or ongoing very low carbohydrate diet (\< 50g/day). * Glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m2 as per CKD-EPI formula with creatinine levels measured within the last 12 months. * Use of hydroxyurea. * Planned or ongoing pregnancy. * Breastfeeding. * Ongoing active risk of recurrent genito-urinary infections, as per the clinical judgement of the investigators. * Severe hypoglycemic episode within 1 month of screening, defined as an event resulting in seizure, loss of consciousness, or need to present to the emergency department. * Diabetic ketoacidosis within 6 months of screening, defined as an event requiring the need to present to medical attention and administration of intravenous insulin. * Any serious medical illness likely to interfere with the ability to complete the trial per the judgment of the investigators. * Clinically significant retinopathy as judged by the investigator. * Recent (\< 3 months) acute macrovascular event (ex: acute coronary syndrome or cardiac surgery). * Prior serious reaction to SGLT2i. * Use of the Medtronic 670G or 770G system in the last 30 days. * In the opinion of the investigator, inability to observe the contraindications of the study drugs, or failure to comply to the study protocol or research team's recommendations (e.g., changing pump parameters, ketone measurements).