Clinical Research Directory

Inclusion Criteria: * ≥ 18 years old * Diagnosis of ALS confirmed according to the revised criteria of El Escorial * Respiratory failure due to diaphragmatic dysfunction treated by non-invasive ventilation for more than a month * Care provided in an ambulatory setting (day care hospital) * Persistent dyspnea at rest ≥ 3 across a numerical scale (0 to 10) in a semi-sitting position * Stable clinical condition, i.e., no episode of acute cardiac, respiratory and/or neurological failure leading to hospitalization in the previous 4 weeks * Free, prior and informed written consent about the study has been obtained * Benefiting a social security (French health insurance system) Exclusion Criteria: * Neurological disorders according to a neurological evaluation dating from less than one year, in particular diagnosed dementia (frontotemporal dementia, Alzheimer's disease, etc.), brain pathology (tumor, stroke, Parkinson's disease, etc.) * Diagnosed psychiatric illness (severe depression, psychosis) or receiving antipsychotic treatment * Acrophobia * Claustrophobia * Photophobia * Hearing loss * Visual impairment * Subject under guardianship or curatorship