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Multimodal Study of the Human Brain Epilepsy Tissue
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The TIPI2 study is a blood and tissue collection protocol to create an annotated biorepository to support research in drug-resistant epilepsy. The aim of the study will be to identify new pathophysiological pathways. For this purpose, the investigators will investigate with a multimodal approach blood and brain samples from patients undergoing a surgery for focal drug-resistant epilepsy. The adult patients will be enrolled either during the pre-surgical evaluation or right before the surgery.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2024-02-29
Completion Date
2037-02-28
Last Updated
2025-07-03
Healthy Volunteers
No
Conditions
Interventions
Blood and tissue collection
Blood will be collected for group 1 during (i) the enrolment visit, (ii) in the 24 hours following a seizure, (iii)before the surgery and (iv) in the 36 months following the surgery. The left-over tissue, not useful for diagnostic purpose, will be kept for research. Blood will be collected for group 2 right before the surgery and in the 36 months following the surgery. The left-over tissue not useful for diagnostic purpose will be kept for research.
Locations (1)
Department of Neurology, Epilepsy Unit, Pitié-Salpêtrière Hospital
Paris, France