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A Novel Therapy With a 1-Month Ultrashort Regimen to Halt Progression From Latent Infection to Active Tuberculosis Among Close Contacts (The TB-YOUTH Study)
Sponsor: Huashan Hospital
Summary
This is a prospective, multi-center, open-label, cluster randomized controlled clinical trial conducted in school settings to estimate the non-inferiority effect of 1H3P3 compared with 3HR.
Key Details
Gender
All
Age Range
13 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3520
Start Date
2023-09-01
Completion Date
2026-09-01
Last Updated
2026-07-14
Healthy Volunteers
No
Conditions
Interventions
isoniazid and rifapentine
12-dose ultra-short TPT 1H3P3 regimen of isoniazid and rifapentine 3 times a week for 4 weeks
Rifampin and Isoniazid
3HR regimen of isoniazid and rifampicin once daily for three months
Locations (66)
People's Hospital of Ziyun
Anshun, Guiyang, China
People's Hospital of Guanling
Anshun, Guizhou, China
People's Hospital of Pingba District
Anshun, Guizhou, China
People's Hospital of Puding
Anshun, Guizhou, China
People's Hospital of Xixiu District
Anshun, Guizhou, China
People's Hospital of Zhenning
Anshun, Guizhou, China
People's Hospital of Hezhang
Bijie, Guizhou, China
People's Hospital of Qianxi
Bijie, Guizhou, China
People's Hospital of Qianxi
Bijie, Guizhou, China
People's Hospital of Weining
Bijie, Guizhou, China
People's Hospital of Zhijin
Bijie, Guizhou, China
People's Hospital of Daozhen Klau and Hmong autonomous county
Daozhen Klau and Hmong Autonomous County in Zun'yi, Guizhou, China
Guiyang Public Health Treatment Center
Guiyang, Guizhou, China
People's Hospital of Baiyun District
Guiyang, Guizhou, China
People's Hospital of Huaxi District
Guiyang, Guizhou, China
People's Hospital of Kaiyang
Guiyang, Guizhou, China
People's Hospital of Wudang District
Guiyang, Guizhou, China
People's Hospital of Xifeng
Guiyang, Guizhou, China
People's Hospital of Xiuwen
Guiyang, Guizhou, China
Liuzhi Special District
Liupanshui, Guizhou, China
People's Hospital of Panzhou
Liupanshui, Guizhou, China
People's Hospital of Shuicheng District, Liupanshui City
Liupanshui, Guizhou, China
Second People's Hospital of Liupanshui City
Liupanshui, Guizhou, China
Third People's Hospital of Liupanshui
Liupanshui, Guizhou, China
People's Hospital of Cengong
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
People's Hospital of Congjiang
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
First People's Hospital of Kaili
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Danzhai
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Huangping
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Jianhe
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Jinping
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Leishan
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Liping
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Rongjiang
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Sansui
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Shibing
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Tianzhu
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Zhenyuan
Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
First People's Hospital of Fuquan
Qiannan, Guizhou, China
People's Hospital of Libo
Qiannan, Guizhou, China
People's Hospital of Luodian
Qiannan, Guizhou, China
People's Hospital of Wanshan District
Tongren, Guizhou, China
Guizhou Aerospace Hospital
Zunyi, Guizhou, China
People's Hospital of Bozhou District
Zunyi, Guizhou, China
People's Hospital of Chishui
Zunyi, Guizhou, China
People's Hospital of Fenggang
Zunyi, Guizhou, China
People's Hospital of Honghuagang District
Zunyi, Guizhou, China
People's Hospital of Meitan
Zunyi, Guizhou, China
People's Hospital of Renhuai
Zunyi, Guizhou, China
People's Hospital of Suiyang
Zunyi, Guizhou, China
People's Hospital of Tongzi
Zunyi, Guizhou, China
People's Hospital of Wuchuan Klau and Hmong autonomous county
Zunyi, Guizhou, China
People's Hospital of Xishui
Zunyi, Guizhou, China
People's Hospital of Yuqing
Zunyi, Guizhou, China
People's Hospital of Zhengan
Zunyi, Guizhou, China
Zunyi Infectious Disease Hospital
Zunyi, Guizhou, China
Zunyi Infectious Disease Hospital
Zunyi, Guizhou, China
Dalian Public Health Clinical Center
Dalian, Liaoning, China
Huashan Hospital
Shanghai, Shanghai Municipality, China
3rd People's Hospital of Bijie
Bijie, China
People's Hospital of Dafang Town
Bijie, China
People's Hospital of Nayong
Bijie, China
Chinese Medicine Hospital of Qingzhen
Guiyang, China
People's Hospital of Majiang
Qiandongnan Miao and Dong Autonomous Region, China
People's Hospital of Taijiang
Qiandongnan Miao and Dong Autonomous Region, China
People's Hospital of Changshun
Qiannan, China