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Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Summary
Massive blood loss occurs in metastatic spinal tumor resection and may cause severe complications. The objective of this study is to investigate whether the use of tranexamic acid will reduce perioperative and postoperative bleeding when compared to those without use of tranexamic acid.
Official title: Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients: a Triple Blinded, Randomized Controlled Trial to Assess the Efficacy of Tranexamic Acid for Hemostasis
Key Details
Gender
All
Age Range
10 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2023-12-01
Completion Date
2026-08-01
Last Updated
2025-02-10
Healthy Volunteers
No
Conditions
Interventions
Tranexamic Acid
IV drip of 2 bottles of tranexamic acid (2g) before making incision during surgery； 1g tranexamic acid soaked gauze applied to the wound for 5 minintes before suture； patients were administered IV drip of tranexamic acid 3 times (every 8 hours)within 24 hours after surgery.
stroke-physiological saline solution (SPSS)
IV drip of 2 bottles of saline before making incision during surgery； saline soaked gauze applied to the wound for 5 minintes before suture； patients were administered IV drip of saline 3 times (every 8 hours)within 24 hours after surgery.
Locations (1)
the Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China