Clinical Research Directory

Inclusion Criteria: * Age 65 and older * Stable medication doses (\>1 month) * Post-menopausal * Clinical Dementia Rating (CDR) of 0 * History of or current metabolic impairment (i.e. metabolic syndrome, pre-diabetes, Type 2 Diabetes, etc) Exclusion Criteria: * Excluded from or unable to complete an MRI scan. MRI compatible pacemakers will require cardiologist clearance prior to enrolling. * ACSM Risk score stratification of "High" unless cleared by a physician prior to participation. * Myocardial infarction or symptoms of coronary artery disease in the last 2 years. * History of or current diagnosis of disorders with the potential to impair cognition (i.e. AD, Parkinson's disease, stroke (defined as clinical episode w/ neuroimaging evidence in appropriate area to explain symptoms)). * Insulin-dependent (Type 1) Diabetes Mellitus. * Clinically significant chronic disease such as cancer, HIV, or acquired immunodeficiency syndrome. * Clinically significant depressive symptoms that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment. * Orthopedic complications that would preclude individuals from safely entering a hot tub. * Untreated hypothyroidism or diseases associated with heat intolerance (i.e. Graves disease, etc). * Contraindication for temperature pill ingestion (i.e. inflammatory bowel disease, diverticulitis or related).