Clinical Research Directory

Inclusion Criteria: * Male or female, 18 years of age or older * Seen in clinical toxicology consultation at the CHU of Martinique during the study period * With an initial chlordeconemia \> 1μg/L on a test less than 1 month old at the time of study inclusion * Affiliated to a social security scheme * Having received informed information on research * Having freely given written and informed consent to participate in the research Exclusion Criteria: * History of cancer * Recent infections less than 6 months old * Known digestive diseases: chronic diarrhoea, ulcerative colitis, Crohn's disease, pancreatitis * Digestive procedures less than 6 months old. * Intrahepatic cholestasis less than 6 months old * Extrahepatic cholestasis less than 6 months old * Use of cholestyramine or ursodeoxycholic acid in the previous 3 months * Consumption of food (non-ordinary yoghurt, etc.) or supplements (tablets, drops, capsules, etc.) containing L. reuteri or any other probiotic within the previous 2 weeks. * Antibiotics taken in the previous 4 weeks. * Immune deficiency secondary to a pathology (lymphoma, leukaemia) or medical treatment (immunosuppressant, corticoid, chemotherapy). * Women who are unable to obtain contraception during the trial * Persons referred to in articles L.1121-5, L.1121-7, L. 1121-8 of the Public Health Code: * Pregnant woman, parturient or breastfeeding mother * Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice) * Persons deprived of their liberty by a judicial or administrative decision, * Persons staying in a health or social care institution for purposes other than research * Persons subject to psychiatric care under Articles L. 3212-1 and L. 3213-1 of the Public Health Code.