Clinical Research Directory

Inclusion Criteria: * Man or woman ≥18 years old and \<90 * If the subject is a woman, she must be on contraception or menopausal. * Non-ST-segment elevation ACS defined by the presence of at least 2 of the following criteria: (1) symptoms of myocardial ischemia, (2) electrocardiographic ST-segment abnormalities (depression or transient elevation of at least 0.1 mV) or T-wave inversion in at least in 2 contiguous leads, or (3) an elevated cardiac troponin value (above the upper limit of normal) 56 or ST segment elevation ACS scheduled for primary PCI defined 57 as a history of chest discomfort or ischemic symptoms of \>20 minutes duration at rest ≤14 days prior to entry into the study with one of the following present on at least one ECG: 1. ST-segment elevation ≥1 mm in two or more contiguous ECG leads 2. New or presumably new left bundle branch block (LBBB). 3. ST-segment depression ≥1 mm in two anterior precordial leads (V1 through V4) with clinical history and evidence suggestive of true posterior infarction * Subject intended for an invasive strategy if NSTE-ACS or primary PCI if STE-ACS according to guidelines (appendix X) * Subject with CKD stage 3A or higher (estimated glomerular filtration rate (eGFR) ≤ 60 ml/min/1.73 m2 according to the CKD-EPI formula * Because of the documented biological variability of eGRF levels, patients with a eGRF \< 78 ml/min/1.73 m2 can be included in this study, based on previous blood test results and on the investigator's decision. The DFG level of 78 ml/min/1.73 m2 correspond to an increase of 30 % of a DFG of 60 ml/min/1.73 m2. Indeed, the literature estimated a DFG levels variability of 30 % 58-61. * Must be enrolled at a cardiac catheterization laboratory hospital or at a hospital/ambulance service affiliated with a cardiac catheterization laboratory hospital. * Subject affiliated to or beneficiary of a social security system. * Subject having signed written informed consent. Exclusion Criteria: * \- Minors, pregnant or breast-feeding women; * Subject under chronic anticoagulant * Subject with thrombolytic therapy during the preceding 24 hours; * Subject with bleeding diathesis; * Subject not agreeing to participate. * Subject with contraindication to clopidogrel, ticagrelor or to another anti platelet agent. * Severe hepatic failure * Ischemic Stroke within one month or a history of hemorrhagic stroke * Platelet count\<100 000 * Major surgery or trauma within 10 days * Life expectancy \<1 year * Known significant bleeding risk according to the physician judgment * Adults subject to a legal protection measure or unable to express their consent (persons under guardianship, curatorship or safeguard of justice) * Persons deprived of their rights of liberty by judicial or administrative decision (persons in a situation of social fragility) * Progressive cancer * Systemic autoimmune disease * Chronic viral or bacterial infections * Diabetes requiring insulin therapy * Constitutional haemorrhagic syndrome * Organ transplantation