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S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC)
Sponsor: Medical University of Warsaw
Summary
The aim of this study is to investigate clinical effects (liver biochemistries, health-related quality of life, liver stiffness) and underlying mechanisms of hepatoprotection of S-adenosylmethionine in patients with primary sclerosing cholangitis. The study will be performed in a randomized and placebo-controlled fashion.
Official title: Clinical Effect and Molecular Mechanisms of Action of S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-08-01
Completion Date
2026-06-01
Last Updated
2025-04-03
Healthy Volunteers
No
Conditions
Interventions
S-Adenosyl-L-methionine (SAMe)
S-adenosyl-L-methionine 1200 mg/daily as 2400mg S-Adenosyl-L-methionine disulfate tosylate
Placebo
Placebo of identical appearance, smell and taste, with the same schedule.
Locations (1)
Department of Hepatology, Transplantology and Internal Medicine, Medical University of Warsaw
Warsaw, Poland