Clinical Research Directory

Inclusion Criteria for Control Subjects: * In good general health * No Active neurological or psychiatric conditions, if a prior neurological or psychiatric condition was present they must have returned to normal * No cognitive complaints * Normal neurological examination * No psychoactive medications * They may have a chronic medical condition that does not affect cognition * Low Aβ load Pittsburgh compound-B (PiB) ratio \<1.5 Inclusion Criteria for Mild Cognitive Impairment Subjects: * In good general health * Memory complaint documented by the patient and collateral source * Normal general cognitive function as determined by measure of general intellectual function and screening including the Short Test of Mental Status * Normal activities of daily living as documented by history and Record of Independent Living * Not demented by DSM-III-R criteria * Do have an objective memory impairment determined by the clinical judgement of the neuropsychologists and neurologists * High Aβ load Pittsburgh compound-B (PiB) ratio ≥1.5 Inclusion Criteria for Alzheimer's Disease Subjects: * In good general health * Dementia not a result of other medical or psychiatric conditions * Diagnosis of dementia made according to DSM-III-R criteria * Do have objective memory impairment determined by the clinical judgement of the neuropsychologists and neurologists * High Aβ load Pittsburgh compound-B (PiB) ratio ≥1.5 Exclusion Criteria: * Alzheimer's disease or mild cognitive impairment due to a known genetic mutation * Major depression * History of primary or metastatic intracranial neoplasm, significant head trauma, intra-cerebral hemorrhage, hemispheric stroke * Contradictions to MRI imaging including but not limited to cardiac pacemakers, intraocular or intracranial metal, or other MRI incompatible devices. * Pregnant women. Women of child bearing potential will be given a urine pregnancy test prior the MRI scan. Results will be shared with the participant. If the pregnancy test is positive, the participant will not be included within the study