Clinical Research Directory

Inclusion Criteria: * Men and women from the age of 30 years * good general condition, no relevant previous diseases * Presence of wrinkles, dermatochalasis on the face, pigment spots, which are an indication for RFMN and thulium laser or comparable methods * Cognitive ability and willingness to give consent (informed consent) * Be willing and able to attend follow-up visits Exclusion Criteria: * Age \< 30 years * Pregnancy or breastfeeding * Excessive subcutaneous fatty tissue under the cheeks * Significant scarring of the region to be treated * open wounds or lesions of the region to be treated * Severe or cystic facial acne * Metallic implants in the face or neck region * Mental illnesses (psychoses, body perception disorders) * Use of isotretinoin or other retinoids, psychotropic drugs, coumarins or heparins in the last 2 weeks * Fillers in the region to be treated \< 4 weeks prior and during the study period * Resurfacing (fractional, ablative, nonablative) of the region of interest \< 2 months prior and during the study period * Plastic aesthetic procedures or other surgical procedures \< 6 months prior and during the study period * Tendency to have excessive scarring * Lack of informed consent