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CD62L Depleted Donor Lymphocyte Infusion With T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation
Sponsor: Hong Kong Children's Hospital
Summary
In this clinical trial, the investigators aim to apply CD62L depleted donor lymphocyte infusion (DLI) together with in vitro T cell depleted haploidentical hematopoietic stem cell transplantation (HSCT) to treat patients with malignant or non-malignant disease in need of HSCT. The investigators shall evaluate the graft failure-free, graft-versus-host disease (GVHD)-free survival at one year, frequency of adverse events and post-transplant complications, and immunoreconstitution.
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
INTERVENTIONAL
Enrollment
23
Start Date
2023-09-01
Completion Date
2026-09
Last Updated
2025-09-15
Healthy Volunteers
No
Conditions
Interventions
CD62L depleted donor lymphocyte infusion
Intravenous infusion of CD62L depleted donor lymphocytes
Locations (1)
Hong Kong Children's Hospital
Hong Kong, Hong Kong