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RECRUITING
NCT06036641

The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics

Sponsor: University of Portsmouth

View on ClinicalTrials.gov

Summary

During certain bowel surgeries for cancer (colorectal surgery), individuals frequently have to be placed in a head-down position to enable surgeons have optimal access to the cancer site. This position usually also involves bending the hips and knees while supporting the legs in stirrups. However, lying in this position for long periods of time can lower the flow of blood to the legs, which can potentially cause injury. This rare but severe consequence is called Well-Leg Compartment Syndrome (WLCS). If WLCS is not diagnosed quickly, it can lead to other difficult complications and a significant delay in recovery. Unfortunately, because the individual is under anaesthesia, diagnosis is delayed in many cases. There is very little information in the medical literature about how this damage to the legs progresses over the course of the surgery. To better understand how WLCS, how well blood vessels work during surgery will be assessed. The flow of blood and oxygen in the calf muscle will be assessed in 25 individuals placed in a head-down position during colorectal surgery. Likewise, blood samples will be obtained in order to measure the biological markers that may contribute to the development of WLCS.

Official title: The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics in Adults Undergoing Minimally Invasive Abdominopelvic Surgery: An Intraoperative Observational Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

25

Start Date

2024-07-22

Completion Date

2025-12

Last Updated

2025-09-12

Healthy Volunteers

No

Interventions

DEVICE

NIRS monitoring

All participants will undergo NIRS monitoring of muscle and cerebral tissue oxygenation intraoperatively.

DEVICE

Laser Doppler flowmetry

Cutaneous blood flow will be assessed intraoperatively via Laser Doppler flowmetry in all participants

OTHER

Inflammatory and Oxidative stress biomarkers

Blood samples will be taken to measure biomarkers of inflammation and oxidative stress at specific time points

Locations (1)

Queen Alexandra Hospital, Portsmouth Hospitals University NHS Trust

Portsmouth, West Sussex, United Kingdom