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Post-Extubation Assessment of Clinical Stability in ELBW Infants
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Summary
This is an observational, proof-of-concept, feasibility study that aims to evaluate the feasibility of a monitoring system that integrates clinical data, high-resolution waveforms from the bedside monitor, regional oxygenation (via cerebral and splanchnic near-infrared spectroscopy), and regional ventilation (via electrical impedance tomography) from 20 extremely low birth weight infants at high-risk of reintubation.
Official title: Post-Extubation Assessment of Clinical Stability in Extremely Preterm Infants: The PEACE Feasibility Study
Key Details
Gender
All
Age Range
Any - 28 Weeks
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2024-10-29
Completion Date
2027-04
Last Updated
2026-03-30
Healthy Volunteers
No
Conditions
Interventions
Oxygen saturation probe
The high-accuracy oxygen saturation signal will be continuously acquired for 168 hours post extubation from a separate pulse oximeter (Radical-7®, Masimo ROOT platform, MasimoCorp, Irvine, LA).
Near infrared spectroscopy sensors
The cerebral and splanchnic regional oxygen saturation signals will be acquired continuously for 168h post extubation using two near infrared spectroscopy sensors (Masimo ROOT platform, MasimoCorp, Irvine, LA), one placed on the forehead for cerebral oxygenation and one on the abdomen (for splanchnic oxygenation).
Electrical impedance tomography
The regional lung ventilation will be measured using Electrical Impedance Tomography (TIMPEL, USA) at three time points: * From 1 hour pre-extubation to 2 hours post extubation (total 3 hours) * Between 24 and 48 hours post extubation (total 3 hours) * Between 72 and 96 hours post extubation (total 3 hours)
Locations (2)
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
McGill University Health Center
Montreal, Quebec, Canada