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NAC vs Placebo on Opioid Use for Hysterectomy
Sponsor: Medical University of South Carolina
Summary
This study will enroll females who are ages 18 and older undergoing a laparoscopic or robotic, partial or full hysterectomy. Participants will be randomized to receive IV n-acetylcysteine or placebo during the first 60 minutes of their procedure. At various time points after the procedure patients will be asked to report their pain scores, and any pain medication taken.
Official title: A Trial Evaluating the Impact of N-acetylcysteine on Opioid Use in Patients Undergoing a Hysterectomy Procedure
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2023-11-30
Completion Date
2026-12-09
Last Updated
2025-10-14
Healthy Volunteers
No
Conditions
Interventions
IV N-acetylcysteine
N-acetylcysteine (NAC) 150 mg/kg (Max dose 15,000 mg) through an IV that will run for 60 minutes at the start of the procedure
IV Placebo
Placebo 0 mg/kg (placebo: 0.45% NaCl or D5W) through an IV that will run for 60 minutes at the start of the procedure.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States