Clinical Research Directory
Browse clinical research sites, groups, and studies.
Investigation of Locus Coeruleus Function in Sustained Attention
Sponsor: University of California, Davis
Summary
The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop methods that permit measurement of activity in the human LC. Because the LC is small and located in the pons, the Investigators will use high resolution magnetic resonance imaging techniques tailored to the brainstem environment, including neuromelanin-sensitive images shown to delineate the LC, combined with pharmacological manipulation to confirm the location of functional activity.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2023-10-01
Completion Date
2025-12-30
Last Updated
2025-12-12
Healthy Volunteers
Yes
Interventions
Modafinil
Single dose (200 mg) of medication versus placebo given to healthy control subjects
Locations (1)
University of California, Davis
Sacramento, California, United States