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Estrogen and Microvascular Function
Sponsor: Medical College of Wisconsin
Summary
The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults. Participants will: * give one blood draw of 5 mL * have one Dexa Scan taken to measure adipose and muscle mass * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen to those who do not.
Official title: Effects of Continuous Estrogen on Human in Vivo Microvascular Function
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
45
Start Date
2023-10-12
Completion Date
2031-12
Last Updated
2025-07-04
Healthy Volunteers
Yes
Interventions
Nω-nitro-L-arginine methyl ester (L-NAME)
L-NAME will be infused locally through microdialysis catheters.
Acetylcholine
ACh will be infused locally through microdialysis catheters.
Sodium Nitroprusside
SNP will be infused locally through microdialysis catheters.
Locations (1)
Froedtert Hospital
Wauwatosa, Wisconsin, United States