Clinical Research Directory

Inclusion Criteria: * ≥ 18 years of age * Histological diagnosis of diffuse glioma (WHO grade 2,3, or 4) * Subjective cognitive impairment, defined as CFQ-score ≥ 44 * Being able to give informed consent and undergo treatment and measurements based on researchers insight * Stable disease, i.e. no oncological treatment for ≤ 2 months prior to inclusion; no radiological progression on the most recent MRI, not older than 6 months, and no clinical progression at inclusion * Stable dosage (for at least 8 weeks) of anti-epileptic medication Exclusion Criteria: * Current pregnancy or have given birth less than three months ago * Current other treatment for cognitive complaints * Karnofsky performance score \<70 * A tumor located in the parietal cortex * TMS exclusion: implanted medical devices (e.g. pacemaker, deep brain stimulator, cochlear implants, medical infusion device, etc.); metal in the body; sleep deprivation * MRI exclusion: extreme claustrophobia or metallic objects in or on the body