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Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Sponsor: University Hospital, Rouen
Summary
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment. Exploring and understanding these data is to improve patient care and discover new therapeutic targets. The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.
Official title: Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons
Key Details
Gender
All
Age Range
Any - 24 Months
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2023-09-26
Completion Date
2026-09-26
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Blood sample
An additionnal volume of blood will be collected at inclusion and at each follow-up visit
Expectoration
Expectoration will be collected at inclusion and at each follow-up visit
Nasopharyngeal swab
A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum
Locations (1)
Rouen University Hospital
Rouen, France