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NCT06045221

PHASE3

A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks.

Official title: A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral LY3502970 Compared With Oral Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-3)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1698

Start Date

2023-09-22

Completion Date

2025-08-22

Last Updated

2026-09-15

Healthy Volunteers

Conditions

Type 2 Diabetes

Interventions

DRUG

Orforglipron

Administered orally

DRUG

Semaglutide

Administered orally

Locations (131)

Absolute Clinical Research

Phoenix, Arizona, United States

San Fernando Valley Health Institute

Canoga Park, California, United States

Neighborhood Healthcare Institute of Health

Escondido, California, United States

Velocity Clinical Research, Gardena

Gardena, California, United States

Biopharma Informatic, LLC

Los Angeles, California, United States

Velocity Clinical Research, Westlake

Los Angeles, California, United States

Infinity Clinical Research - Norco

Norco, California, United States

Valley Clinical Trials, Inc.

Northridge, California, United States

Norcal Endocrinology & Internal Medicine

San Ramon, California, United States

Encompass Clinical Research

Spring Valley, California, United States

University Clinical Investigators, Inc.

Tustin, California, United States

New West Physicians Clinical Research

Golden, Colorado, United States

Connecticut Clinical Research - Cromwell

Cromwell, Connecticut, United States

Clinical Research of West Florida, Inc. (Clearwater)

Clearwater, Florida, United States

South Florida Clinical Research Institute

Margate, Florida, United States

Miami Dade Medical Research Institute, LLC

Miami, Florida, United States

West Orange Endocrinology

Ocoee, Florida, United States

Latin Clinical Trial Center Florida

Tamarac, Florida, United States

Clinical Research of West Florida

Tampa, Florida, United States

Metabolic Research Institute, Inc.

West Palm Beach, Florida, United States

Balanced Life Health Care Solutions/SKYCRNG

Lawrenceville, Georgia, United States

Clinical Research Atlanta

Stockbridge, Georgia, United States

North Georgia Clinical Research

Woodstock, Georgia, United States

Northwest Clinical Trials

Boise, Idaho, United States

Family First Medical Center

Idaho Falls, Idaho, United States

American Health Network of Indiana, LLC - Greenfield

Greenfield, Indiana, United States

Velocity Clinical Research, Valparaiso

Valparaiso, Indiana, United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, United States

Tekton Research, Inc

Wichita, Kansas, United States

DelRicht Research

New Orleans, Louisiana, United States

Joslin Diabetes Center

Boston, Massachusetts, United States

Revival Research Institute, LLC

Dearborn, Michigan, United States

SKY Integrative Medical Center/SKYCRNG

Ridgeland, Mississippi, United States

Kansas City Research Institute

Kansas City, Missouri, United States

Logan Health Research

Kalispell, Montana, United States

Wr-Crcn, Llc

Las Vegas, Nevada, United States

Premier Research

Trenton, New Jersey, United States

Albany Medical College, Division of Community Endocrinology

Albany, New York, United States

Ellipsis Research Group - Brooklyn - 7th Street

Brooklyn, New York, United States

Great Lakes Medical Research, LLC

Westfield, New York, United States

PharmQuest Life Sciences, LLC

Greensboro, North Carolina, United States

Lucas Research, Inc

Morehead City, North Carolina, United States

Accellacare - Piedmont

Statesville, North Carolina, United States

Wake Forest University Baptist Medical Center (WFUBMC)

Winston-Salem, North Carolina, United States

Aventiv Research Inc

Columbus, Ohio, United States

Tekton Research, Inc

Moore, Oklahoma, United States

Alliance for Multispecialty Research, LLC

Norman, Oklahoma, United States

The Corvallis Clinic, P.C.

Corvallis, Oregon, United States

Heritage Valley Medical Group, Inc.

Beaver, Pennsylvania, United States

Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)

Pittsburgh, Pennsylvania, United States

The Research Center of The Upstate

Greenville, South Carolina, United States

New Phase Research and Development

Knoxville, Tennessee, United States

Clinical Neuroscience Solutions Inc.

Memphis, Tennessee, United States

Velocity Clinical Research, Austin

Austin, Texas, United States

Velocity Clinical Research, Dallas

Dallas, Texas, United States

Diabetes and Thyroid Center of Ft. Worth

Fort Worth, Texas, United States

Juno Research

Houston, Texas, United States

Endocrine Ips, Pllc

Houston, Texas, United States

Clear Brook Medical Associates

Houston, Texas, United States

Southern Endocrinology Associates

Mesquite, Texas, United States

Texas Valley Clinical Research

Weslaco, Texas, United States

Synexus Clinical Research US, Inc.

Salt Lake City, Utah, United States

Eastside Research Associates

Redmond, Washington, United States

Rainier Clinical Research Center

Renton, Washington, United States

Centro de Investigaciones Metabólicas (CINME)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

CIMeL

Lanus, Buenos Aires, Argentina

Centro de Investigaciones Médicas Mar del Plata

Mar del Plata, Buenos Aires, Argentina

Policlinica Red OMIP

Mar del Plata, Buenos Aires, Argentina

Consultorio de Investigación Clínica EMO SRL

Buenos Aires, Buenos Aires F.D., Argentina

CIPREC

Buenos Aires, Buenos Aires F.D., Argentina

Centro Médico Viamonte

Buenos Aires, Buenos Aires F.D., Argentina

Instituto Centenario

CABA, Buenos Aires F.D., Argentina

Centro de Salud e Investigaciones Médicas

Santa Rosa, La Pampa Province, Argentina

INECO Neurociencias Oroño