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EEG Microstates Across At-Risk Mental States
Sponsor: Centre Hospitalier St Anne
Summary
The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6). The main questions it aims to answer are: * are EEG microstate anomalies associated with diagnosis, clinical and functional prognosis, both in resting conditions and during sleep ? * are EEG microstates anomalies associated with differences in sensorimotor integration, prosodic and conversational, interoceptive, and narrative self ? * an ancillary study will be to see whether in healthy controls EEG microstate properties vary under light hypnosis conditions. Participants will: * undergo deep phenotyping based on psychopathology and neuropsychological assessments * undergo a high-resolution EEG (64 electrodes) with a resting period and a sensorimotor task; and healthy controls will have a light hypnosis period. * undergo a recording of the characteristics of their voice (tone, prosody) * undergo a one-night polysomnography * undergo MRI and biological sampling for multi-omic analyses * undergo a virtual reality experience
Official title: Determination of EEG Microstates Associated With Mental Disorders in At-Risk States (Détermination Des Microétats EEG associés Aux Troubles Psychiques Dans Les États à Risque - DEMETER)
Key Details
Gender
All
Age Range
15 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
126
Start Date
2023-05-30
Completion Date
2026-07-30
Last Updated
2023-09-21
Healthy Volunteers
Yes
Interventions
EEG 64 channels
64-channel EEG in wake and resting conditions for 1h30, with oculogram, electromyogram and electromyogram and electrocardiogram. Five minutes of eyes closed will be used for microstate analysis. 1h30 will be used for the sensorimotor task.
Polysomnography 19 electrodes
Overnight polysomnography with 19 EEG channels and ventilatory polygraphy.
Light hypnosis
Healthy controls will undergo a 5 min light hypnosis exercise that will be focused on proprioception.
Biological sampling
Blood samples will be taken for genetic, epigenetic, proteomic, and metabolomic studies.
Virtual reality
Participants will undergo a virtual reality task using a head-mounted display, and their multidimensional self will be assessed prior to and after the task via the self-reference effect on episodic memory.
Voice recording
A double channel audio recorder will be used during 30 min to assess voice characteristics of all subjects.
Locations (1)
Centre de Recherche Clinique, Hôpital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences
Paris, France