Clinical Research Directory

Inclusion Criteria: * Lower extremity amputation performed more than 12 months before study enrollment * PLP/RLP in affected amputated limb \> 4 on NRS26 * Pain duration of more than 6 months despite a trial of conservative therapies for at least 2 months, including oral medications, topical medicines, physical therapy, and physical modalities (i.e., heat, cold, transcutaneous electrical nerve stimulation, phonophoresis) * Willingness to undergo image guided diagnostic nerve block Exclusion Criteria: * Refusal / inability to participate or provide consent * Contraindications to diagnostic nerve block * Non-neurogenic source of PLP/RLP * Current opioid use \> 50 morphine milligram equivalents per day * Any interventional pain treatment in the residual limb within the last 30 days * Severe uncontrolled medical condition (i.e., hypertensive crisis, decompensated hypothyroidism) * Use of investigational pain drug within past 30 days or other concurrent clinical trial enrollment