Clinical Research Directory

Inclusion Criteria * ≥ 18 years of age * Moderate-to-severe OSA * Available to attend study visits and sessions * Reliable access to a phone Exclusion Criteria * Prior or current use of PAP therapy or other treatment (e.g., oral appliance) for OSA * History of upper airway surgery for OSA * Moderate to severe insomnia * Commercial drivers * Use of non-standard PAP including adaptive servo-ventilation or bi-level positive airway pressure * Report of motor vehicle accident or near-miss due to sleepiness within the 2 previous years * Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and/or congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression) * Other sleep disorders (e.g., circadian rhythm disorder) * Use of supplemental oxygen during wakefulness or sleep * Central sleep apnea, obesity hypoventilation syndrome or Cheyne-Stokes respiration based on the home sleep apnea test * Resting awake oxygen saturation (SpO2) \< 90% * Participation in another clinical trial