Clinical Research Directory

Inclusion Criteria: 1. Provision of signed and dated informed consent form directly by the patient; consent can also be obtained via a legal patient representative/health care proxy/surrogate 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or female, aged 18 or older 4. Diagnosed with hypercapnic respiratory failure on admission (ABG) 5. Admitted to Lenox Hill Hospital medical intensive care unit or telemetry unit 6. Requiring noninvasive ventilation as determined by the treating physician for the treatment of hypercarbic respiratory failure Exclusion Criteria: 1. Patients who require ventilation at predetermined tidal volumes 2. Patients who require rapid and frequent IPAP adjustments to maintain a consistent tidal volume 3. Age less than 18 years of age 4. Currently intubated 5. Chronic tracheostomy 6. Pregnancy 7. Hypotension 8. Epistaxis (nosebleed) 9. Untreated pertussis 10. Acute sinusitis or Otitis media 11. Patients at risk of aspirating gastric contents 12. Patients with lack of spontaneous respiratory drive 13. Patients with the inability to maintain a patent airway or adequately clear secretions 14. Prisoners or other institutionalized individuals