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Enterics for Global Health (EFGH)
Sponsor: University of Washington
Summary
Diarrhea remains a leading cause of death among young children, with the majority of diarrhea deaths occurring in low- and middle-income countries. Childhood diarrhea caused by a type of bacteria called "Shigella" is responsible for an estimated 60,000 deaths each year and may cause particularly severe illness among children. Currently, there are several promising vaccines to prevent Shigella diarrhea in development, but key information is still needed to inform future vaccine studies. The purpose of this study, titled Enterics for Global Health (or the "EFGH"), is to determine the number and rate of new cases of Shigella diarrhea among children 6 to 35 months of age presenting to health facilities with diarrhea or dysentery. Over a two-year period, the EFGH study will enroll 1,400 children from each of the seven countries: Peru, Pakistan, Bangladesh, Mali, Malawi, Kenya, and The Gambia (9,800 children total).
Official title: The Incidence and Burden of Shigella Diarrhea in Children Aged 6-35 Months: the Enterics for Global Health (EFGH) - Shigella Burden Study
Key Details
Gender
All
Age Range
6 Months - 35 Months
Study Type
OBSERVATIONAL
Enrollment
9800
Start Date
2022-08-25
Completion Date
2025-04-30
Last Updated
2025-01-14
Healthy Volunteers
No
Locations (33)
Dhaka Medical College Hospital
Dhaka, Bangladesh
EFGH Field Clinic
Dhaka, Bangladesh
icddr,b Dhaka Hospital
Dhaka, Bangladesh
Mugda Medical College Hospital
Dhaka, Bangladesh
Sir Salimullah Medical College Hospital
Dhaka, Bangladesh
Abidha Health Center
Siaya, Kenya
Akala Health Center
Siaya, Kenya
Bar Agulu Health Center
Siaya, Kenya
Dienya Health Centre
Siaya, Kenya
Lwak Mission Hospital
Siaya, Kenya
Ongielo Health Centre
Siaya, Kenya
Siaya County Referral Hospital
Siaya, Kenya
Ting Wangi Health Center
Siaya, Kenya
Wagai Health Center
Siaya, Kenya
Ndirande Health Centre
Blantyre, Malawi
Asacodjeneka Cscom
Bamako, Mali
Asacodjip Cscom
Bamako, Mali
Banconi CSCOM (ASACOBA)
Bamako, Mali
CSREF Commune 1
Bamako, Mali
Abbasi Shaheed Hospital
Karachi, Pakistan
Ali Akbar Shah Center
Karachi, Pakistan
Bhains colony AKU site
Karachi, Pakistan
Khidmat e Alam Medical Centre
Karachi, Pakistan
Sindh Government Hospital, Ibrahim Hyderi
Karachi, Pakistan
Sindh Government Hospital, Korangi
Karachi, Pakistan
America Health Post
Iquitos, Maynas, Peru
Hospital de Apoloyo
Iquitos, Maynas, Peru
Modelo Health Post
Iquitos, Maynas, Peru
Progreso Health Post
Iquitos, Maynas, Peru
San Juan Health Post
Iquitos, Maynas, Peru
Santo Tomas Health Post
Iquitos, Maynas, Peru
Basse Hospital
Basse Santa Su, Upper River Division, The Gambia
Gambisara Health Centre (HC)
Basse Santa Su, Upper River Division, The Gambia