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ACTIVE NOT RECRUITING
NCT06047821

Enterics for Global Health (EFGH)

Sponsor: University of Washington

View on ClinicalTrials.gov

Summary

Diarrhea remains a leading cause of death among young children, with the majority of diarrhea deaths occurring in low- and middle-income countries. Childhood diarrhea caused by a type of bacteria called "Shigella" is responsible for an estimated 60,000 deaths each year and may cause particularly severe illness among children. Currently, there are several promising vaccines to prevent Shigella diarrhea in development, but key information is still needed to inform future vaccine studies. The purpose of this study, titled Enterics for Global Health (or the "EFGH"), is to determine the number and rate of new cases of Shigella diarrhea among children 6 to 35 months of age presenting to health facilities with diarrhea or dysentery. Over a two-year period, the EFGH study will enroll 1,400 children from each of the seven countries: Peru, Pakistan, Bangladesh, Mali, Malawi, Kenya, and The Gambia (9,800 children total).

Official title: The Incidence and Burden of Shigella Diarrhea in Children Aged 6-35 Months: the Enterics for Global Health (EFGH) - Shigella Burden Study

Key Details

Gender

All

Age Range

6 Months - 35 Months

Study Type

OBSERVATIONAL

Enrollment

9800

Start Date

2022-08-25

Completion Date

2025-04-30

Last Updated

2025-01-14

Healthy Volunteers

No

Locations (33)

Dhaka Medical College Hospital

Dhaka, Bangladesh

EFGH Field Clinic

Dhaka, Bangladesh

icddr,b Dhaka Hospital

Dhaka, Bangladesh

Mugda Medical College Hospital

Dhaka, Bangladesh

Sir Salimullah Medical College Hospital

Dhaka, Bangladesh

Abidha Health Center

Siaya, Kenya

Akala Health Center

Siaya, Kenya

Bar Agulu Health Center

Siaya, Kenya

Dienya Health Centre

Siaya, Kenya

Lwak Mission Hospital

Siaya, Kenya

Ongielo Health Centre

Siaya, Kenya

Siaya County Referral Hospital

Siaya, Kenya

Ting Wangi Health Center

Siaya, Kenya

Wagai Health Center

Siaya, Kenya

Ndirande Health Centre

Blantyre, Malawi

Asacodjeneka Cscom

Bamako, Mali

Asacodjip Cscom

Bamako, Mali

Banconi CSCOM (ASACOBA)

Bamako, Mali

CSREF Commune 1

Bamako, Mali

Abbasi Shaheed Hospital

Karachi, Pakistan

Ali Akbar Shah Center

Karachi, Pakistan

Bhains colony AKU site

Karachi, Pakistan

Khidmat e Alam Medical Centre

Karachi, Pakistan

Sindh Government Hospital, Ibrahim Hyderi

Karachi, Pakistan

Sindh Government Hospital, Korangi

Karachi, Pakistan

America Health Post

Iquitos, Maynas, Peru

Hospital de Apoloyo

Iquitos, Maynas, Peru

Modelo Health Post

Iquitos, Maynas, Peru

Progreso Health Post

Iquitos, Maynas, Peru

San Juan Health Post

Iquitos, Maynas, Peru

Santo Tomas Health Post

Iquitos, Maynas, Peru

Basse Hospital

Basse Santa Su, Upper River Division, The Gambia

Gambisara Health Centre (HC)

Basse Santa Su, Upper River Division, The Gambia