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Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement
Sponsor: Hunter Holmes Mcguire Veteran Affairs Medical Center
Summary
Hypothesis: Improvement in cognitive dysfunction with IV albumin in patients with cirrhosis with prior HE and MHE lasts for several weeks after albumin infusion has ended, and is due to persistent improvement in inflammatory markers, endothelial dysfunction, albumin function and gut microbial changes. This will be a single-arm, single-blind sequential trial of IV 25% albumin and IV saline over 8 weeks with biological sampling and cognitive and health related quality of life (HRQOL) testing with each subject acting as their own control.
Official title: Randomized Clinical Trial in Hepatic Encephalopathy to Study Lasting Cognitive Improvement With Intravenous Albumin
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-11-02
Completion Date
2026-12-01
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
Albumin Infusion
Intravenous human serum albumin to be given at 1.5g/kg ideal body weight
Locations (1)
Hunter Holmes McGuire VA Medical Center
Richmond, Virginia, United States