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Serial Brain MRI in Hospitalized Preterm Infants
Sponsor: Brigham and Women's Hospital
Summary
The purpose of this research study is to use serial magnetic resonance imaging (MRI) to define the timing and factors associated with brain injury as well as the pattern of brain growth of very preterm infants during hospitalization in the neonatal intensive care unit (NICU). In addition, the goal is to utilize early MRI to risk-stratify preterm infants and tailor rehabilitative interventions according to risk in order to explore associations between NICU rehabilitative intervention and short- and long-term outcomes of preterm infants.
Official title: Serial Neuroimaging of Brain Injury and Brain Growth in the NICU in the Very Preterm Infant
Key Details
Gender
All
Age Range
22 Weeks - 33 Weeks
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2020-09-14
Completion Date
2029-09-14
Last Updated
2026-03-25
Healthy Volunteers
No
Conditions
Interventions
SENSE-plus: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program
The SENSE II program was developed to engage parents in consistently providing positive, developmentally appropriate sensory exposures to their high-risk infants in the NICU every day of hospitalization. The SENSE II program includes specific doses and targeted timing (based on postmenstrual age) of evidence-based interventions of auditory, tactile, vestibular, kinesthetic, olfactory, and visual exposures to be conducted daily through hospitalization for preterm infants. Additionally, for very preterm infants with advanced neurological injury, additional 1-2 sessions of weekly motor therapy are added to the SENSE-II program
SENSE: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program
The SENSE II program was developed to engage parents in consistently providing positive, developmentally appropriate sensory exposures to their high-risk infants in the NICU every day of hospitalization. The SENSE II program includes specific doses and targeted timing (based on postmenstrual age) of evidence-based interventions of auditory, tactile, vestibular, kinesthetic, olfactory, and visual exposures to be conducted daily through hospitalization for preterm infants.
Reference/ Standard of care
Infants in the Unexposed group receive the NICU standard of developmental care throughout hospitalization.
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States