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Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
Sponsor: Australian and New Zealand Intensive Care Research Centre
Summary
The DIRECT trial is a prospective, multi-centre, two arm parallel feasibility pilot randomised controlled trial. The primary aim is to determine the feasibility of using repeat indirect calorimetry measurements to direct energy delivery in critically ill patients with obesity. The trial will recruit 60 mechanically ventilated patients from 4-6 ICUs in Australia and New Zealand.
Official title: GuiDIng Energy Provision Using indiREct CalorimeTry: a Pilot Feasibility Randomised Controlled Trial in Critically Ill Adults With Obesity
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-10-02
Completion Date
2026-06
Last Updated
2025-07-25
Healthy Volunteers
No
Conditions
Interventions
Indirect calorimetry
Weekly indirect calorimetry measurements using the Q-NRG+ device will be used to guide energy delivery up to day 28 of hospital admission.
Indirect calorimetry (Standard care nutrition arm)
Weekly indirect calorimetry measurements using the Q-NRG+ device will be conducted up to day 28 of hospital admission. In the standard care nutrition arm, clinicians will be blinded to indirect calorimetry measurements.
Locations (5)
Blacktown Hospital
Blacktown, New South Wales, Australia
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
Ballarat Base Hospital, Grampians Health
Ballarat Central, Victoria, Australia
The Alfred Hospital
Melbourne, Victoria, Australia
Department of Critical Care Medicine, Auckland City Hospital
Auckland, New Zealand