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ACTIVE NOT RECRUITING
NCT06054529

Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients

Sponsor: AdventHealth Translational Research Institute

View on ClinicalTrials.gov

Summary

To learn how altered metabolism in GBM causes tumor growth and resistance to drug therapy. In this pilot research study, we will dose GBM patients with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We will measure how fast the nicotinamide is converted to methyl nicotinamide. We believe that the speed of this chemical reaction in the tumor (fast versus slow) may be correlated with GBM aggressiveness

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

2

Start Date

2023-09-11

Completion Date

2025-12

Last Updated

2025-03-13

Healthy Volunteers

Not specified

Conditions

Glioblastoma Multiforme

Interventions

PROCEDURE

Surgical removal of the GBM tumor

Surgical removal of the GBM tumor

OTHER

d4-NAM infusion

Following the surgical removal of the GBM tumor, GBM patients will be dosed with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We will measure how fast the nicotinamide is converted to methyl nicotinamide. We believe that the speed of this chemical reaction in the tumor (fast versus slow) may be correlated with GBM aggressiveness.

Locations (1)

AdventHealth Translational Research Institute

Orlando, Florida, United States