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Methadone Pharmacokinetics in End-stage Renal Disease
Sponsor: Pontificia Universidad Catolica de Chile
Summary
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the management of acute postoperative pain. After surgery the participants will use an IV-PCA of methadone and blood samples will be withdrawn to measure the plasmatic levels of it. The main question the study aims to answer is: • Is the pharmacokinetic of methadone used in an IV-PCA pump impaired in patients with chronic kidney disease?
Official title: Postoperative Pharmacokinetics of Methadone in Patients With Chronic Kidney Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2024-04-05
Completion Date
2024-12-31
Last Updated
2024-05-10
Healthy Volunteers
No
Interventions
Preoperative step
* Explanation of the surgery and use of the IV-PCA pump. * Signed informed consent.
Intraoperative
Bolus of methadone 0.1mg/kg based on ideal body weight (up to a maximum dose of 20 mg), at the beginning of surgery.
Post-operative
Installation of IV-PCA of methadone. Program to be used with no background infusion, boluses of 1 mg, and the intervals between boluses of 8 minutes.
Locations (1)
Pontificia Universidad Católica de Chile
Santiago, Chile