Clinical Research Directory

Inclusion Criteria: * Paroxysmal atrial fibrillation documented in ECG or Holter monitoring * Deceleration capacity \>7.5ms * Life expectancy more than 1 year * Age ≥18 years Exclusion Criteria: * Permanent AF lasting more than one year or persistent AF lasting more than 7 days * AF secondary to electrolyte imbalance, thyroid disease, alcohol abuse, or other non-heart related causes * Anteroposterior dimension of the left atrium in the echocardiography ≥43mm * Clinically significant arrhythmias other than AF * Significant valvular disease * Valve prosthesis * Heart failure III or IV Class in New York Heart Association Classification * Previous ablation of atrial fibrillation or atrial flutter * History of a patent foramen ovale/atrial septal defect closure * History of left atrial appendage closure * Atrial myxoma * Presence of a cardiac pacemaker, defibrillator or cardiac resynchronization therapy device * History of pericarditis * Congenital heart disease * History of bleeding or coagulation disorders * Contraindications to oral anticoagulation * Contraindications to computed tomography or magnetic resonance imaging * Pregnancy or breast-feeding * BMI\>31 * History of transplantation * Severe lung disease * Chronic renal failure defined as estimated glomerular filtration rate (eGFR) \<30 mL/min/m2 * Cancer * Significant infection * Life expectancy less than one year * Mental disorders * Lack of informed consent to participate in the trial