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Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders
Sponsor: Nantes University Hospital
Summary
Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.
Official title: Relationship Between Premorbid Personality Traits and Cognitive and Behavioral Disorders
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2023-10-01
Completion Date
2027-02-01
Last Updated
2023-10-03
Healthy Volunteers
No
Conditions
Interventions
Submission of the NEO-PI-3 questionnaire
The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree).
Submission of the Interpersonal Reactivity Index questionnaire (IRI)
The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.