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An Organoid-based Functional Precision Medicine Trial in Osteosarcoma
Sponsor: Jonsson Comprehensive Cancer Center
Summary
The purpose of this study is to examine if we can predict sensitivity of osteosarcoma to different chemotherapy agents using tissue cultures in the laboratory. We know that different chemotherapy agents can be used in the treatment, but not every sarcoma responds to them equally. It is important to understand if testing of the tissue obtained during a routine biopsy or surgery may be useful in selecting appropriate treatments. In addition, additional testing of the tumor, including genetic testing, will help us to understand osteosarcoma better.
Official title: An Organoid-based Functional Precision Medicine Trial in Osteosarcoma: PREMOST
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2024-02-12
Completion Date
2028-01-01
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
standard of care biopsy
Image-guided or surgical biopsy of the lesion that is suspected to be osteosarcoma in a patient with localized disease (Group 1)
standard of care biopsy
Image-guided or surgical biopsy or excision of the lesion that is suspected to be recurrent or metastatic osteosarcoma (Group 2).
Locations (1)
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States