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Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Dementia with Lewy body disease (DLB) is the second leading cause of degenerative cognitive disorder after Alzheimer's disease (AD). Its variable clinical expression makes diagnosis difficult. To date, there is no validated DLB diagnostic biomarker, despite several biomarkers in development (EEG, MRI, biology). Studies have shown that an improvement in diagnostic performance could be obtained by combining different modalities biomarkers using machine learning. The aim of this research is to identify the best combination of multimodal biomarkers for the diagnosis of DLB (EEG, MRI, biology, cognitive scores), using a machine learning approach applied to a clinical cohort.
Official title: Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach: EEG, Cognitive, Biological and MRI Biomarkers
Key Details
Gender
All
Age Range
55 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
130
Start Date
2024-09-11
Completion Date
2027-09
Last Updated
2025-03-27
Healthy Volunteers
No
Interventions
EEG
32-electrode EEG (resting state, passive auditory and active visual task) + simultaneous recording with a 4 dry electrode EEG cap
Locations (1)
Centre de neurologie Cognitive
Paris, France, France