Clinical Research Directory

Inclusion Criteria: 1. Age 18 years or older 2. CNS injury with onset in the prior 90 days 1. For stroke: Stroke that is radiologically verified and due to ischemia or to intracerebral hemorrhage. 2. For traumatic brain injury: History that is consistent with TBI; and score on the Revised Rancho Levels of Cognitive Functioning Scale is at least 6 out of 10. 3. For spinal cord injury: Traumatic or nontraumatic, incomplete cervical SCI. 3. At least one arm must have motor deficits that are neither very mild nor devastating (dense arm plegia). Operationally, this requires that the Visit 1 Box \& Block Test score is at least 1 block, but no more than 30 blocks, in 60 seconds. 4. Possess enough arm movement to participate in therapy, including able to hold the HandyMotion device in the paretic hand(s), using an assistive device if needed. 5. Informed consent signed by the subject (no surrogate consent permitted for this study) 6. Able to follow simple instructions 7. Study participation is not likely to be significantly limited by agitated behavior Exclusion Criteria: 1. A major, active, coexistent neurological or psychiatric disease that would limit study participation, e.g., advanced dementia or active psychosis 2. Expectation that patient's cognitive status will likely interfere substantially with playing assigned games or exercises 3. Deficits in communication that interfere with reasonable study participation 4. Lacking visual acuity, with or without corrective lens, of 20/50 or better in at least one eye 5. Subject does not speak sufficient English to comply with study procedures 6. Shoulder pain that in the judgement of the study team is likely to substantially limit the amount of TR therapy completed