Clinical Research Directory

Inclusion Criteria: * Pathologically confirmed diagnosis of breast cancer * Age: 18 to 70 years old * No infiltration of the nipple-areola complex and negative histopathology of the nipple basal margins; * Participants who meet the indications for breast conserving surgery require total mastectomy and reconstruction; Exclusion Criteria: * Inability to tolerate surgery or subjective desire not to undergo nipple-sparing mastectomy; * Participants with clinical or imaging evidence of preoperative involvement of the nipple/areolar region, including Paget's disease, nipple spillage, inflammatory breast cancer, and/or imaging findings suggesting malignant involvement of the nipple or subareolar tissues, according to the 2023 NCCN guideline recommendations, where retaining the NAC fails to yield negative margins;