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CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study
Sponsor: Ionis Pharmaceuticals, Inc.
Summary
The main purpose of this study is to measure the amyloid burden, defined as extracellular volume (ECV) assessed by Magnetic Resonance Imaging (MRI) over time in a subset of up to 150 participants enrolled in ION-682884-CS2 (NCT04136171).
Official title: The CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2021-03-31
Completion Date
2026-04
Last Updated
2025-11-28
Healthy Volunteers
No
Interventions
Cardiac MRI
MRI Scans as specified in the corresponding arm group.
Locations (11)
Brigham and Women's Hospital
Boston, Massachusetts, United States
Oregon Health and Science University
Portland, Oregon, United States
Azienda Ospedaliero - Universitaria Careggi
Florence, Italy
Azienda Ospedale Università di Padova
Padova, Italy
Hospital Universitario Puerta de Hierro
Majadahonda, Spain
Synexus - Scotland Clinical Research Centre
Bellshill, United Kingdom
Synexus Midlands Clinical Research Centre
Birmingham, United Kingdom
Synexus - Wales
Cardiff, United Kingdom
Royal Free London NHS Foundation Trust
London, United Kingdom
Richmond Pharmacology
London, United Kingdom
Synexus - Manchester Clinical Research Centre
Manchester, United Kingdom