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The CARDIO-TTRansform Scintigraphy Sub-study
Sponsor: Ionis Pharmaceuticals, Inc.
Summary
The purpose of this study is to examine the changes in amyloid myocardial burden in a subset of the population participating in the ION682884-CS2 (NCT04136171) study, up to 150 participants, after treatment with eplontersen or placebo based on scintigraphy scans performed at Week 140 using the Perugini grade score method.
Official title: CARDIO-TTRansform ION-682884-CS2-Scintigraphy Sub-study
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2023-04-04
Completion Date
2026-03
Last Updated
2025-11-28
Healthy Volunteers
No
Interventions
Scintigraphy scan
Scans will be performed as specified in the arm description.
Locations (5)
Columbia University Irving Medical Center
New York, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Cleveland Clinic Main Campus
Cleveland, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
Hospital Universitario Puerta de Hierro
Majadahonda, Spain