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Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
Sponsor: University of California, San Francisco
Summary
The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25. The main question it aims to answer is: will cannabis users who switch to less potent THC products demonstrate improved cognitive function compared to baseline? Other questions this study aims to answer include: * Can researchers accurately assess THC consumption among frequent cannabis users? * Can researchers effectively incentivize cannabis users to use less potent THC products? * Do genetic variations in THC metabolism impact urinary THC excretion? * Do genetic variations in THC metabolism impact cognitive performance in cannabis users? * Are quantitative urinary THC values predictive of cognitive impairment? * How can researchers use research findings to inform harm reduction practices for people who use cannabis? Participants will submit blood and urine samples and be incentivized to use less potent THC products.
Official title: Impacts of THC Potency of Cannabis Concentrates and THC Metabolism on Cognitive Impairment in Young Adults
Key Details
Gender
All
Age Range
21 Years - 25 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2025-03-17
Completion Date
2026-03-14
Last Updated
2025-10-24
Healthy Volunteers
Yes
Interventions
15% THC Potency Reduction
Participants will be incentivized to use THC products that are at least 15% less potent than baseline
35% THC Potency Reduction
Participants will be incentivized to use THC products that are at least 35% less potent than baseline
Locations (1)
University of California San Francisco
San Francisco, California, United States