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A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
Sponsor: Boehringer Ingelheim
Summary
This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet. The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight. Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity. Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants' cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects.
Official title: A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, and/or at Least Two Weight-related Complications or Risk Factors for CVD
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
5533
Start Date
2023-11-20
Completion Date
2026-06-22
Last Updated
2026-04-02
Healthy Volunteers
No
Conditions
Interventions
survodutide
once weekly subcutaneous injection, pre-filled syringe
Placebo
once weekly subcutaneous injection, pre-filled syringe
Locations (540)
Cardiology P.C.
Birmingham, Alabama, United States
AMR Daphne
Daphne, Alabama, United States
AMR Mobile
Mobile, Alabama, United States
Mobile Heart Specialists, PC
Mobile, Alabama, United States
The Institute for Liver Health II DBA Arizona Clinical Trials
Chandler, Arizona, United States
Clinical Research Institute of Arizona, LLC
Sun City West, Arizona, United States
AMR Phoenix
Tempe, Arizona, United States
Arizona Liver Health-Tucson-67516
Tucson, Arizona, United States
Yuma Clinical Trials
Yuma, Arizona, United States
Lynn Institute of the Ozarks
Little Rock, Arkansas, United States
Velocity Clinical Research-Huntington Park
Huntington Park, California, United States
Velocity Clinical Research, San Diego
La Mesa, California, United States
Velocity Clinical Research - Los Angeles
Los Angeles, California, United States
Catalina Research Institute, LLC
Montclair, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
NorCal Endocrinology and Internal Medicine
San Ramon, California, United States
Velocity Clinical Research, Santa Ana
Santa Ana, California, United States
NorthBay Clinical Research, LLC
Santa Rosa, California, United States
Velocity Clinical Research-Van Nuys-70286
Van Nuys, California, United States
Peak Gastroenterology Associates-Colorado Springs-62256
Colorado Springs, Colorado, United States
Bridgeport Hospital
Bridgeport, Connecticut, United States
CMR of Greater New Haven, LLC
Hamden, Connecticut, United States
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Proactive Clinical Research
Boca Raton, Florida, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Clinical Research of West Florida, Inc.
Clearwater, Florida, United States
Nature Coast Clinical Research-Crystal River-62355
Crystal River, Florida, United States
Beautiful Minds Clinical Research Center
Cutler Bay, Florida, United States
AMR Fort Myers
Fort Myers, Florida, United States
Covenant Metabolic Specialists, LLC - Fort Myers
Fort Myers, Florida, United States
Velocity Clinical Research-Hallandale Beach-67888
Hallandale, Florida, United States
Westside Center for Clinical Research
Jacksonville, Florida, United States
Clinical Site Partners LLC
Leesburg, Florida, United States
Suncoast Research Group
Miami, Florida, United States
Verus Clinical Research Corporation
Miami, Florida, United States
Center for Diabetes, Obesity and Metabolism
Pembroke Pines, Florida, United States
Synexus-Pinellas Park-69294
Pinellas Park, Florida, United States
East Coast Institute for Research, LLC-Saint Augustine-63032
Saint Augustine, Florida, United States
Lenus Research & Medical Group
Sweetwater, Florida, United States
Santos Research Center, Corp.
Tampa, Florida, United States
Covenant Metabolic Specialists, LLC - Sarasota
University Park, Florida, United States
Javara-Albany-67356
Albany, Georgia, United States
Centricity Research Columbus Georgia Multispecialty
Columbus, Georgia, United States
Javara-Fayetteville-67354
Fayetteville, Georgia, United States
NSC Research Inc
Johns Creek, Georgia, United States
The Jones Center Clinical Research, LLC
Macon, Georgia, United States
Urban Family Practice Associates, PC
Marietta, Georgia, United States
Javara-Savannah-67450
Savannah, Georgia, United States
Endeavor Health Clinical Operations - Northwest Community Healthcare
Arlington Heights, Illinois, United States
Cedar Crosse Research Center
Chicago, Illinois, United States
Research by Design, LLC
Chicago, Illinois, United States
Medisphere Medical Research Center
Evansville, Indiana, United States
McFarland Clinic PC
Ames, Iowa, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States
AMR El Dorado
El Dorado, Kansas, United States
AMR Newton
Newton, Kansas, United States
AMR Clinical Wichita
Wichita, Kansas, United States
Research Integrity, LLC
Owensboro, Kentucky, United States
Grace Research, LLC-Bossier City-51040
Bossier City, Louisiana, United States
Heart Clinic of Hammond
Hammond, Louisiana, United States
Tandem Clinical Research
Marrero, Louisiana, United States
AMR New Orleans
New Orleans, Louisiana, United States
Grace Research, LLC-Shreveport-64616
Shreveport, Louisiana, United States
Javara Inc.-Annapolis-68997
Annapolis, Maryland, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
MD Medical Research
Oxon Hill, Maryland, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Domino's Farms
Ann Arbor, Michigan, United States
Elite Research Center, LLC
Flint, Michigan, United States
Healthy Heart Cardiology
Grand Rapids, Michigan, United States
Mayo Clinic, Rochester
Rochester, Minnesota, United States
The National Diabetes & Obesity Research Institute
Diamondhead, Mississippi, United States
Prime Health and Wellness
Fayette, Mississippi, United States
Velocity Clinical Research-Gulfport-68930
Gulfport, Mississippi, United States
Clinical Research Consultants, LLC
Kansas City, Missouri, United States
AMR Kansas City
Kansas City, Missouri, United States
Clinvest Research LLC
Springfield, Missouri, United States
Sundance Clinical Research, LLC
St Louis, Missouri, United States
Mercury Street Medical
Butte, Montana, United States
Skyline Medical Center
Elkhorn, Nebraska, United States
Methodist Physicians Clinic
Fremont, Nebraska, United States
AMR Las Vegas
Las Vegas, Nevada, United States
Advanced Heart Care, LLC
Bridgewater, New Jersey, United States
NJ Heart LLC
Linden, New Jersey, United States
IMA Clinical Research-Warren-69742
Warren Township, New Jersey, United States
IMA Clinical Research Albuquerque
Albuquerque, New Mexico, United States
Velocity Clinical Research - Binghamton
Binghamton, New York, United States
Synexus Clinical Research US, Inc.
New York, New York, United States
Saratoga Clinical Research, LLC
Saratoga Springs, New York, United States
Accellacare of Cary
Cary, North Carolina, United States
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Javara-Charlotte-67884
Charlotte, North Carolina, United States
Accellacare-Mooresville-69123
Mooresville, North Carolina, United States
Centricity Research (New Bern)
New Bern, North Carolina, United States
Wake Forest University Health Sciences-Winston-Salem-69719
Winston-Salem, North Carolina, United States
Velocity Clinical Research-Cincinnati-69044
Cincinnati, Ohio, United States
Synexus Clinical Research-Columbus-69427
Columbus, Ohio, United States
Centricity Research-Columbus-68879
Columbus, Ohio, United States
Aventiv Research Inc.-Dublin-62009
Dublin, Ohio, United States
Clinical Research Institute of Ohio, LLC
Westlake, Ohio, United States
Tekton Research-Edmond-68875
Edmond, Oklahoma, United States
AMR Norman
Norman, Oklahoma, United States
Lynn Institute of Norman
Norman, Oklahoma, United States
Lynn Health Science Institute
Oklahoma City, Oklahoma, United States
South Oklahoma Heart Research Group
Oklahoma City, Oklahoma, United States
Velocity Clinical Research-Medford-69053
Medford, Oregon, United States
Heritage Valley Medical Group
Beaver, Pennsylvania, United States
Capital Area Research, LLC
Camp Hill, Pennsylvania, United States
Tristar Clinical Investigations PC
Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians-Pittsburgh-63932
Pittsburgh, Pennsylvania, United States
Preferred Primary Care Physicians-Uniontown-69137
Uniontown, Pennsylvania, United States
Velocity Clinical Research-East Greenwich-68873
East Greenwich, Rhode Island, United States
Synexus - Anderson
Anderson, South Carolina, United States
Velocity Clinical Research-Anderson-69093
Anderson, South Carolina, United States
Velocity Clinical Research-Gaffney-69046
Gaffney, South Carolina, United States
Tribe Clinical Research LLC
Greenville, South Carolina, United States
Velocity Clinical Research-Greenville-69045
Greenville, South Carolina, United States
Coastal Carolina Research Center
North Charleston, South Carolina, United States
Velocity Clinical Research-Union-68888
Union, South Carolina, United States
Internal Medicine and Pediatric Associates of Bristol, PC
Bristol, Tennessee, United States
Chattanooga Research & Medicine, PLLC
Chattanooga, Tennessee, United States
Alliance for Multispecialty Research, LLC-Knoxville-69693
Knoxville, Tennessee, United States
Accellacare of Knoxville-Knoxville-69135
Knoxville, Tennessee, United States
Accellacare of Knoxville-Knoxville-69714
Knoxville, Tennessee, United States
Clinical Neuroscience Solutions, Inc-Memphis-65988
Memphis, Tennessee, United States
Clinical Research Associates, Inc
Nashville, Tennessee, United States
Amarillo Medical Specialists
Amarillo, Texas, United States
Velocity Clinical Research, Austin
Austin, Texas, United States
Headlands Research
Brownsville, Texas, United States
Privia Medical Group Gulf Coast, PLLC
Conroe, Texas, United States
Velocity Clinical Research-Dallas-69170
Dallas, Texas, United States
Javara Inc. - Fort Worth
Fort Worth, Texas, United States
Houston Research Institute
Houston, Texas, United States
IMA Clinical Research San Antonio
San Antonio, Texas, United States
Tekton Research-San Antonio-68916
San Antonio, Texas, United States
Javara Inc. and Privia Medical Group Gulf Coast, PLLC
San Marcos, Texas, United States
Javara Inc.-Stephenville-68996
Stephenville, Texas, United States
DM Clinical Research - Martin Diagnostic Clinic
Tomball, Texas, United States
Velocity Clinical Research, Waco
Waco, Texas, United States
Physicians' Research Options. LLC
Draper, Utah, United States
Alliance for Multispecialty Research, LLC-Layton-69691
Layton, Utah, United States
Synexus Clinical Research-Salt Lake City-69293
Salt Lake City, Utah, United States
Chrysalis Clinical Research
St. George, Utah, United States
Velocity Clinical Research-West Jordan-69043
West Jordan, Utah, United States
Washington Center for Weight Management and Research, Inc.
Arlington, Virginia, United States
Seven Corners Medical Center
Falls Church, Virginia, United States
Eastern Virginia Medical School
Norfolk, Virginia, United States
Selma Medical Associates, Winchester
Winchester, Virginia, United States
Velocity Clinical Research, Seattle
Seattle, Washington, United States
Velocity Clinical Research-Spokane-69716
Spokane, Washington, United States
Clinical Investigation Specialists, Inc.-Kenosha-69111
Kenosha, Wisconsin, United States
Allegiance Research Specialists
Wauwatosa, Wisconsin, United States
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553
C.a.b.a, Argentina
CEDIC - Centro de Investigacion Clinica
CABA, Argentina
Mautalen- Salud e Investigacion
CABA, Argentina
Centro Medico Dra Laura Maffei
Ciudad Autonoma Buenos Aires, Argentina
Glenny Corp. S.A. Bioclinica Argentina
Ciudad Autonoma Buenos Aires, Argentina
Centro Medico Viamonte
Ciudad Autonoma de Bs As, Argentina
Sanatorio Güemes
Ciudad Autonoma de Bs As, Argentina
Consultorio de Investigacion Clinica EMO SRL
Ciudad Autonoma de Buenos Aire, Argentina
CIPREC
Ciudad Autonoma de Buenos Aire, Argentina
CIDIM - Centro Integral de Diagnostico por Imagenes Marchegiani
Córdoba, Argentina
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, Argentina
Instituto de Investigaciones Clinicas Mar del Plata
Mar del Plata, Argentina
Hospital Privado - Centro Medico de Cordoba S.A.
Parque Velez Sarsfield, Argentina
CEMEDIC - Centro de Especialidades Medicas
Villa Luro, Argentina
The Boden Initiative
Camperdown, New South Wales, Australia
Novatrials
Charlestown, New South Wales, Australia
Royal North Shore Hospital-St Leonards-66471
St Leonards, New South Wales, Australia
Momentum Clinical Research - Taringa
Taringa, Queensland, Australia
Momentum Clinical Research Taringa
Wellers Hill, Queensland, Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Advara Heart Care-Leabrook-69072
Leabrook, South Australia, Australia
Victorian Heart Hospital
Clayton, Victoria, Australia
Royal Melbourne Hospital
Parkville, Victoria, Australia
Advara Heart Care-Joondalup-69073
Joondalup, Western Australia, Australia
Southern Adelaide Diabetes & Endocrine services
Oaklands Park, Australia
Medical University Graz
Graz, Austria
Medical University of Innsbruck
Innsbruck, Austria
Convent Hospital Barmherzige Brüder
Linz, Austria
LKH Salzburg University Hospital
Salzburg, Austria
Hospital Stockerau
Stockerau, Austria
Klinik Landstrasse
Vienna, Austria
Private Practice - Dr. Ursula Hanusch-Enserer
Vienna, Austria
AKH - Medical University of Vienna
Vienna, Austria
AZ Sint-Jan Brugge
Bruges, Belgium
Edegem - UNIV UZ Antwerpen
Edegem, Belgium
UZ Leuven
Leuven, Belgium
Hospital Universitário João de Barros Barreto
Belém, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda.
Brasília, Brazil
Chronos Pesquisa Clinica
Brasília, Brazil
Cline Research Center
Curitiba, Brazil
Instituto de Estudos e Pesquisas Clínicas IEP-CE
Fortaleza, Brazil
Instituto Brasil de Pesquisa Clinica (IBPClin)
Rio de Janeiro, Brazil
ISPEM - Instituto São Jose dos Campos em Pesquisas Medicas
São José dos Campos, Brazil
Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
São Paulo, Brazil
Cpquali Pesquisa Clinica Ltda
São Paulo, Brazil
BR Trials
São Paulo, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
São Paulo, Brazil
Hospital das Clinicas da Faculdade de Medicina da USP
São Paulo, Brazil
MHAT "Yuliya Vrevska" EOOD, Byala
Byala, Bulgaria
MHAT - Dobrich, AD
Dobrich, Bulgaria
Multy profile hospital for active treatment Sv.Ivan Rilski
Dupnitsa, Bulgaria
Multiprofile Hospital for Active Treatment Trimontsium OOD
Plovdiv, Bulgaria
MHAT "St. Caridad"
Plovdiv, Bulgaria
Multy Profile Hospital for active treatment Hadzhi Dimirar
Sliven, Bulgaria
Diagnostic & Consultancy Center "Ascendent", Sofia
Sofia, Bulgaria
Alexandrovska University Hospital
Sofia, Bulgaria
Diagnostic Consultative Center Alexandrovska
Sofia, Bulgaria
UMHAT "Tsaritsa Yoanna-ISUL" EAD
Sofia, Bulgaria
ASOMHIDC - Individual practice "Cardio Tonus" EOOD
Sofia, Bulgaria
Medical Center Synexus Sofia EOOD
Sofia, Bulgaria
Medical Center Berbatov
Yambol, Bulgaria
MHAT St Panteleimon
Yambol, Bulgaria
Richmond Road Diagnostic & Treatment Centre
Calgary, Alberta, Canada
C-ENDO Diabetes & Endocrinology Clinic
Calgary, Alberta, Canada
CARe Clinic (Red Deer)
Red Deer, Alberta, Canada
SMH Cardiology Clinical Trials Inc.
Surrey, British Columbia, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, Canada
Winnipeg Clinic
Winnipeg, Manitoba, Canada
QEII Health Sciences Centre
Halifax, Nova Scotia, Canada
Centricity Research (Brampton)
Brampton, Ontario, Canada
Cambridge Cardiac Care Centre
Cambridge, Ontario, Canada
Centricity Research (Etobicoke)
Etobicoke, Ontario, Canada
Premier Clinical Trial Network
Hamilton, Ontario, Canada
The Wharton Medical Clinic Clinical Trials Inc.
Hamilton, Ontario, Canada
Western Centre for Public Health & Family Medicine (LHRI)
London, Ontario, Canada
Centricity Research (Oshawa)
Oshawa, Ontario, Canada
Bluewater Clinical Research
Sarnia, Ontario, Canada
Canadian Phase Onward Inc.
Toronto, Ontario, Canada
Centricity Research (Bayview)
Toronto, Ontario, Canada
Diabetes Heart Research Centre
Toronto, Ontario, Canada
Clinical Research Solutions Inc. (Waterloo)
Waterloo, Ontario, Canada
Ecogene-21
Chicoutimi, Quebec, Canada
Montreal Heart Institute
Montreal, Quebec, Canada
Montreal General Hospital - McGill University Health Centre
Montreal, Quebec, Canada
Centre de Medecine Metabolique de Lanaudiere
Terrebonne, Quebec, Canada
Diex Recherche (Trois-Rivieres)
Trois-Rivières, Quebec, Canada
Recherche Clinique Sigma Inc.
Québec, Canada
Beijing Chao-Yang Hospital
Beijing, China
Peking University First Hospital
Beijing, China
Beijing Pinggu Hospital
Beijing, China
The Second Hospital of Jilin University
Changchun, China
Changzhou Second People's Hospital
Changzhou, China
Second Affiliated Hospital Chongqing Medical University
Chongqing, China
Hangzhou First People's Hospital
Hangzhou, China
Forth Clinical Hospital of Harbin Medical University
Harbin, China
The First Affiliated Hospital of University of South China
Hengyang, China
Huai'an first people's hospital
Huai'an, China
Huzhou Central Hospital
Huzhou, China
Center Hospital of Jinan
Jinan, China
Lishui Municipal Central Hospital
Lishui, China
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, China
Nanchang People's Hospital
Nanchang, China
Nanjing Drum Tower Hospital
Nanjing, China
Zhongda Hospital Southeast University
Nanjing, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, China
Nanjing Jiangning Hospital
Nanjing, China
The First Affiliated Hospital of Nanyang Medical College
Nanyang, China
The First Affiliated Hospital of Ningbo University
Ningbo, China
First Hospital of Qinhuangdao
Qinhuangdao, China
Zhongshan Hospital Affiliated to Fudan University
Shanghai, China
Tongren hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China
Shanghai Municipal Hospital of Traditional Chinese Medicine
Shanghai, China
Shanghai Fifth People's Hospital affiliated to Fudan University
Shanghai, China
Shanghai Pudong New District People's Hospital
Shanghai, China
The Second Hospital of Hebei Medical University
Shijiazhuang, China
Suzhou Science & Technology Town Hospital
Suzhou, China
Shaanxi Provincial People's Hospital
Xi'an, China
First Affiliated Hospital of Xi'an JiaoTong University
Xi'an, China
The First Affiliated Hospital of Xi'an Medical University
Xi'an, China
Xianyang Hospital of Yan'an University
Xianyang, China
Affiliated Hospital of Jiangsu University
Zhenjiang, China
St. Anna Hospital
Brno, Czechia
DIKa centrum s.r.o.
Havířov, Czechia
Center for Osteoporosis Therapy
Karlovy Vary, Czechia
Diabetology Krnov
Krnov, Czechia
Internal and Diabetes Clinic
Náchod, Czechia
PreventaMed, s.r.o.
Olomouc, Czechia
University Hospital Ostrava
Ostrava-Poruba, Czechia
Internal ambulance Dialine s.r.o.
Pilsen, Czechia
Synexus Czech s.r.o.
Prague, Czechia
General Faculty Hospital, Prague
Prague, Czechia
OB Klinika
Prague, Czechia
Institute for Clinical and Experimental Medicine-Prague-66083
Prague, Czechia
ResTrial s.r.o.
Prague, Czechia
Aarhus University Hospital
Aarhus N, Denmark
Copenhagen University Hospital, Rigshospitalet
Copenhagen, Denmark
Herlev and Gentofte Hospital
Herlev, Denmark
Regionshospitalet Gødstrup
Herning, Denmark
Hvidovre Hospital
Hvidovre, Denmark
CRST Helsinki Oy
Helsinki, Finland
StudyCor Oy
Jyväskylä, Finland
Terveystalo Pori Lääkäritalo
Pori, Finland
Tampere University Hospital
Tampere, Finland
Terveystalo Pulssi, Turku
Turku, Finland
Universitätsklinikum Aachen, AöR
Aachen, Germany
Velocity Clinical Research Germany GmbH, Berlin
Berlin, Germany
DRK Kliniken Berlin Köpenick
Berlin, Germany
Synexus Clinical Research GmbH, Berlin
Berlin, Germany
Universitätsklinikum Köln (AöR)
Cologne, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, Germany
Universitätsklinikum Erlangen
Erlangen, Germany
Synexus Clinical Research GmbH, Frankfurt
Frankfurt, Germany
IKF Pneumologie GmbH & Co. KG
Frankfurt, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
Medizinische Hochschule Hannover
Hanover, Germany
St. Josefskrankenhaus Heidelberg
Heidelberg, Germany
Universität des Saarlandes
Homburg, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, Germany
Synexus Clinical Research GmbH, Leipzig
Leipzig, Germany
Velocity Clinical Research Germany GmbH, Leipzig
Leipzig, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, Germany
Westfälische Wilhelms-Universität Münster
Münster, Germany
CEDA Research GBR
Pohlheim, Germany
Universitätsklinikum Tübingen
Tübingen, Germany
General Hospital of Athens "Laiko"
Athens, Greece
Attikon University Hospital
Haidari-Athens, Greece
University General Hospital of Heraklion
Heraklion, Crete, Greece
Univ. Gen. Hosp. of Ioannina
Ioannina, Greece
General University Hospital of Larissa
Larissa, Greece
Iatriko of Athens Group/ Iatriko of P. Faliro
P. Faliro, Greece
Iatriko Psychikou
Psychikó, Greece
Gen. Hosp. of Thessaloniki "Hippokation", Department of Endocrinology
Thessaloniki, Greece
University General Hospital of Thessaloniki AHEPA
Thessaloniki, Greece
Prince of Wales Hospital-Hong Kong-20715
Hong Kong, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong
Tung Wah Hospital
Hong Kong, Hong Kong
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, Hungary
Obudai Egeszegugyi Centrum Kft.
Budapest, Hungary
Synexus Hungary Healthcare Service Ltd.
Budapest, Hungary
Central Hospital of Northern Pest - Military Hospital
Budapest, Hungary
Bajcsy-Zsilinszky Hospital and Clinic
Budapest, Hungary
Semmelweis University
Budapest, Hungary
University Debrecen Hospital
Debrecen, Hungary
Erzsebet Nursing Home
Gödöllő, Hungary
Synexus Hungary Healthcare Service Ltd
Gyula, Hungary
Trial Pharma Kft
Gyula, Hungary
BKS Research Ltd
Hatvan, Hungary
Studium Egeszseghaz Kft.
Kalocsa, Hungary
Somogy County Kaposi Mor Teaching Hospital
Kaposvár, Hungary
Obudai Egeszegugyi Centrum
Zalaegerszeg, Hungary
SYNEXUS Hungary Health Care Services Ltd-Zalaegerszeg-69406
Zalaegerszeg, Hungary
Kamalnayan Bajaj Hospital
Aurangabad, India
S.P. Medical College & Associated Group of Hospitals
Bikaner, India
Apollo Speciality Hospital
Chennai, India
LPS Institute of Cardiology
Kanpur, India
Shrikrishna Hrudayalaya and Critical Care Centre
Maharashtra, India
Batra Hospital and Medical Research Centre
New Delhi, India
Sir Gangaram Hospital
New Delhi, India
Shri B.D. Mehta Mahavir Heart Institute
Surat, India
St. Vincent's University Hospital
Dublin, Ireland
University Hospital Galway
Galway, Ireland
Humanitas Gavazzeni
Bergamo, Italy
Ospedale S.M. Goretti
Latina, Italy
IRCCS MultiMedica
Milan, Italy
Centro Cardiologico Monzino-IRCCS
Milan, Italy
Policlinico "Paolo Giaccone"
Palermo, Italy
Università Campus Bio-Medico - ROMA
Roma, Italy
AOU Policlinico Umberto I
Roma, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
A.O.U. Senese
Siena, Italy
Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
Torino, Italy
Meitetsu Hospital
Aichi, Nagoya, Japan
Nagoya Kyoritsu Hospital
Aichi, Nagoya, Japan
Chubu Rosai Hospital
Aichi, Nagoya, Japan
Daido Clinic
Aichi, Nagoya, Japan
Seikeikai New Tokyo Heart Clinic
Chiba, Matsudo, Japan
Takagi Hospital
Fukuoka, Okawa, Japan
Seino Internal Medicine Clinic
Fukushima, Koriyama, Japan
Iryouhouijneiwakai Minamiakatsuka Clinic
Ibaraki, Mito, Japan
Matsuba Clinic
Kanagawa, Kawasaki, Japan
Sagamihara Kyodo Hospital
Kanagawa, Sagamihara, Japan
Saiseikai Yokohamashi Nanbu Hospital
Kanagawa, Yokohama, Japan
Takeshita Hospital
Kochi, Kochi, Japan
Kyoto Okamoto Memorial Hospital
Kyoto, Kuse-gun, Japan
Sato Hospital
Miyagi, Sendai, Japan
Urasoe General Hospital
Okinawa, Urasoe, Japan
Osaka Keisatsu Hospital
Osaka, Osaka, Japan
Saiseikai Kawaguchi Hospital
Saitama, Kawaguchi, Japan
Koshigaya Municipal Hospital
Saitama, Koshigaya, Japan
Saitama Sekishikai Hospital
Saitama, Sayama, Japan
Sayama General Clinic
Saitama, Sayama, Japan
Omihachiman Community Medical Center
Shiga, Omihachiman, Japan
Minamino Cardiovascular Hospital
Tokyo, Hachioji, Japan
NewHeart Watanabe Institute
Tokyo, Suginami-ku, Japan
Saiseikai Wakayama Hospital
Wakayama, Wakayama, Japan
Institute of Gastroenterology, Hepatology and Metabolism LLP
Almaty, Kazakhstan
Academy of Preventive Medicine, Clinic "Vitalem"
Almaty, Kazakhstan
Multidisciplinary City Hospital №1 of the Akimat of Astana
Astana, Kazakhstan
National Research Medical Center (NNMC)
Astana, Kazakhstan
Medical Center Metas S.C.
Chihuahua City, Mexico
Instituto de Diabetes, Obesidad y Nutrición S.C.
Cuernavaca, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
Culiacán, Mexico
Clinica Omega Diabetes
Mexico City, Mexico
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
México, Mexico
Cardiolink Clin Trials S.C.
Monterrey, Mexico
Rijnstate Hospital
Arnhem, Netherlands
Spaarne Ziekenhuis
Haarlem, Netherlands
Diakonessenhuis Utrecht
Utrecht, Netherlands
Maxima Medisch Centrum
Veldhoven, Netherlands
P3 Research Palmerston North
Palmerston North, Migration Data, New Zealand
Optimal Clinical Trials
Auckland, New Zealand
Pacific Clinical Research Network - Forte Christchurch
Christchurch, New Zealand
Momentum Clinical Research
Lower Hutt, New Zealand
Middlemore Clinical Trials
Papatoetoe, New Zealand
Pacific Clinical Research Network - Rotorua
Rotorua, New Zealand
P3 Research Kapiti
Waikanae Beach, New Zealand
Vestre Viken HF, Drammen Sykehus
Drammen, Norway
Akershus Universitetssykehus HF
Lørenskog, Norway
St. Olavs Hospital, Universitetssykehuset i Trondheim
Trondheim, Norway
Sykehuset i Vestfold, Avd. Tønsberg
Tønsberg, Norway
Medical University of Bialystok
Bialystok, Poland
Trial Medica
Bialystok, Poland
Centrum Medyczne Intercor Sp. z o.o.
Bydgoszcz, Poland
NZOZ Medical Center KERmed
Bydgoszcz, Poland
Synexus Poland, Branch in Czestochowa
Częstochowa, Poland
Synexus Polska SCM Sp. z o.o. Gdansku, Gdansk
Gdansk, Poland
Synexus Polska Sp. z o.o. Oddzial w Gdyni, Gdynia
Gdynia, Poland
Przychodnie Grudziadz sp.zo.o
Grudziądz, Poland
Synexus Polska Sp. z o.o. Oddzial w Katowicach, Katowice
Katowice, Poland
Silmedic Sp. z o.o.
Katowice, Poland
Vita Longa Sp. z o.o.
Katowice, Poland
Salvia Lekston I Madej Sp. J.
Katowice, Poland
Diab-Endo-Met Medical Center
Krakow, Poland
Unicardia Specialist Medical Center
Krakow, Poland
Synexus Lodz Medical Center
Lodz, Poland
Med-Gastr Medical Center
Lodz, Poland
Clinical Best Solutions
Lublin, Poland
Ekamed Sp. z o.o.
Lublin, Poland
Futuremeds Sp. z o.o. Olsztyn
Olsztyn, Poland
Synexus Poland, Branch in Poznan
Poznan, Poland
Metabolic Health Center Pawel Bogdanski
Poznan, Poland
Private Practice Dr. Ewa Krzyzagorska
Poznan, Poland
Padre Pio Regional Hospital in Przemysl
Przemyśl, Poland
Centrum Medyczne Medyk
Rzeszów, Poland
Velocity Nova Sp. z.o.o.
Skierniewice, Poland
NZOZ Procordis, Cardiology Research Center of Sopot
Sopot, Poland
Velocity Nova Sp z o.o.
Staszów, Poland
DC-MED
Swidnica, Poland
Clinical Best Solutions Sp. z o.o. S.K.
Warsaw, Poland
NBR Polska
Warsaw, Poland
National Medical Institute MSWiA
Warsaw, Poland
Centrum Medyczne Synexus
Warsaw, Poland
ETG Warszawa
Warsaw, Poland
Synexus Poland, Branch in Wroclaw
Wroclaw, Poland
Hospital de Cascais Dr. José de Almeida
Alcabideche, Portugal
ULS da Região de Aveiro
Aveiro, Portugal
ULS Braga
Braga, Portugal
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
Coimbra, Portugal
ULS do Alto Ave
Guimarães, Portugal
ULS de São José
Lisbon, Portugal
APDP - Associação Protectora dos Diabéticos de Portugal
Lisbon, Portugal
Hospital da Luz
Lisbon, Portugal
Cardiolima - Centro Diagnostico Cardio-pulmonar de Ponte de Lima, Lda.
Ponte de Lima, Portugal
ULS de Entre Douro e Vouga
Santa Maria da Feira, Portugal
UCARDIO
Torres Novas, Portugal
Hospital da Luz Arrábida
Vila Nova de Gaia, Portugal
Advanced Clinical Research
Bayamón, Puerto Rico
Ponce School of Medicine/CAIMED Center
Ponce, Puerto Rico
King Fahad Specialist Hospital - Research Center
Dammam, Saudi Arabia
King AbdulAziz University Hospital
Jeddah, Saudi Arabia
King Faisal Specialist Hospital and Research Center
Riyadh, Saudi Arabia
King Saud Medical City
Riyadh, Saudi Arabia
METABOL KLINIK s.r.o., Bratislava
Bratislava, Slovakia
MEDISPEKTRUM s.r.o., Bratislava
Bratislava, Slovakia
Medical Group Kosice s.r.o
Košice, Slovakia
IN-DIA s.r.o., Lucenec
Lučenec, Slovakia
Funkystuff s.r.o.
Nové Zámky, Slovakia
DIAB sro
Rožňava, Slovakia
Pusan National University Hospital
Busan, South Korea
Chungbuk National University Hospital
Cheongju-si, South Korea
Keimyung University Dongsan Hospital
Daegu, South Korea
Yeungnam University Medical Center
Daegu, South Korea
Chungnam National University Hospital
Daejeon, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Seoul National University Bundang Hospital
Seongnam, South Korea
Kyung Hee University Hospital
Seoul, South Korea
Korea University Anam Hospital
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea
Kyung Hee University Hospital at Gangdong
Seoul, South Korea
Gangnam Severance Hospital
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Hospital General Universitario de Alicante
Alicante, Spain
Hospital Universitario de Badajoz
Badajoz, Spain
Centro Médico Teknon
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Clínic de Barcelona
Barcelona, Spain
Hospital de Basurto
Bilbao, Spain
Hospital Universitari de Girona Doctor Josep Trueta
Girona, Spain
Hospital Universitario San Cecilio
Granada, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Spain
Hospital Quirónsalud Madrid
Pozuelo de Alarcón, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Complexo Hospitalario Universitario De Santiago
Santiago de Compostela, Spain
Hospital Quironsalud Infanta Luisa
Seville, Spain
Hospital Dr. Peset
Valencia, Spain
Chang-Hua Christian Hospital
Changhua, Taiwan
Chia-Yi Christian Hospital
Chia-Yi City, Taiwan
NCKUH
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Chang Gung Memorial Hospital, Linkou
Taoyuan, Taiwan
Adana City Hospital
Adana, Turkey (Türkiye)
Baskent University Hospital
Adana, Turkey (Türkiye)
Akdeniz UTF Endokrinoloji ve Metabolizma Hastaliklari BD
Antalya, Turkey (Türkiye)
Inonu Uni. Med. Fac., Battalgazi
Battalgazi, Turkey (Türkiye)
Bursa Yuksek Ihtisas EAH
Bursa, Turkey (Türkiye)
Dicle Universitesi Tip Fakultesi
Diyarbakır, Turkey (Türkiye)
Koc Universitesi Hastanesi
Istanbul, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa Tip Fakultesi-Istanbul-1433
Istanbul, Turkey (Türkiye)
Acibadem Universitesi Atakent Hastanesi
Istanbul, Turkey (Türkiye)
İstanbul Prof.Dr. Cemil Taşçıoğlu City Hospital
Istanbul, Turkey (Türkiye)
Istanbul Universitesi Istanbul Tip Fakultesi
Istanbul, Turkey (Türkiye)
Marmara Universitesi Tip Fakultesi
Istanbul, Turkey (Türkiye)
Zonguldak Bulent Ecevit UTF
Zonguldak, Turkey (Türkiye)
University Hospital Monklands
Airdrie, United Kingdom
Antrim Area Hospital
Antrim, United Kingdom
Waterloo Medical Centre
Blackpool, United Kingdom
Synexus - Cardiff
Cardiff, United Kingdom
Synexus - Lancashire
Chorley, United Kingdom
Ninewells Hospital & Medical School
Dundee, United Kingdom
Synexus - Midlands
Edgbaston, United Kingdom
Wellcome Trust Clinical Research Facility, Edinburgh
Edinburgh, United Kingdom
Queen Elizabeth University Hospital
Glasgow, United Kingdom
Synexus - Glasgow
Glasgow, United Kingdom
Synexus - Hexham
Hexham, United Kingdom
Leicester General Hospital
Leicester, United Kingdom
Lincoln County Hospital
Lincoln, United Kingdom
Synexus - Merseyside
Liverpool, United Kingdom
William Harvey Research Limited
London, United Kingdom
Altnagelvin Area Hospital
Londonderry, United Kingdom
Manchester Royal Infirmary
Manchester, United Kingdom
Synexus - Manchester
Manchester, United Kingdom
Royal Victoria Infirmary
Newcastle upon Tyne, United Kingdom
FutureMeds - Newcastle
Newcastle upon Tyne, United Kingdom
Swansea University Medical School
Swansea, United Kingdom
University Hospital Wishaw
Wishaw, United Kingdom