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The Effects of Antibiotic Exposure in Early Infancy on Vaccine Responses
Sponsor: Landspitali University Hospital
Summary
This prospective cohort study will include 200 term children born in Landspitali University Hospital in Iceland. The cohort will be divided into four groups according to antibiotic exposure of which one is the control group. Children's immune responses to live oral rotavirus vaccine as well as conventional vaccinations given at three, five and 12 months old will be determined by measuring salivary and serologic responses. Responses will be compared between the four groups. Stool samples will also be collected from participants and the composition of the microbiome compared between the four groups.
Key Details
Gender
All
Age Range
Any - 6 Weeks
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2022-09-10
Completion Date
2027-12-31
Last Updated
2025-12-18
Healthy Volunteers
Yes
Conditions
Interventions
Antibiotic treatment
Children will be assigned to groups according to antibiotic exposure in early life. No antibiotics will be given in the study.
Locations (1)
Landspitali University Hospital
Reykjavik, Iceland