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The Beneficial Value of PET/CT in the Follow-up of Stage III Non-small Cell Lung Cancer Patients
Sponsor: Radboud University Medical Center
Summary
The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F-Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography (18F FDG PET/CT) versus follow-up with conventional CT surveillance. Participants will receive usual care until 3 years of follow-up (control group) with additional whole-body 18F FDG PET/CT scans during follow-up visits at 6 months, 12 months, 18 months, 24 months, and 36 months of follow-up in the intervention group. Other tasks include: * filling in quality of life (QOL) questionnaires at every time point; * participating in an interview evaluating the addition of the 18F FDG PET/CT scans (optional); * collecting blood at the follow-up time points for our secondary endpoint (optional). Researchers will compare the usual care control group with the intervention group to see if the additional 18F FDG PET/CT scans are (cost-)effective.
Official title: The Beneficial Value of 18F FDG PET/CT in the Follow-up of Stage III Non-small Cell Lung Cancer Patients: the NVALT31-PET Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
690
Start Date
2024-03-19
Completion Date
2029-06
Last Updated
2025-02-05
Healthy Volunteers
No
Conditions
Interventions
18F FDG PET/CT
Additional 18F FDG PET/CT scans during follow-up visits at 6, 12, 18, 24 and 36 months of follow-up.
CT scan
CT of the thoracic region during follow-up visits at 6, 12, 18, 24 and 36 months of follow-up.
Locations (27)
Tergooi MC
Hilversum, Utrecht, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
Antoni van Leeuwenhoek/Nederlands Kanker Instituut
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
Gelre Ziekenhuizen
Apeldoorn & Zutphen, Netherlands
Amphia Ziekenhuis
Breda, Netherlands
Deventer Ziekenhuis
Deventer, Netherlands
Ziekenhuis Gelderse Vallei
Ede, Netherlands
Máxima Medisch Centrum
Eindhoven & Veldhoven, Netherlands
Treant
Emmen, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
Groene Hart Ziekenhuis
Gouda, Netherlands
Martini Ziekenhuis
Groningen, Netherlands
Tjongerschans ziekenhuis
Heerenveen, Netherlands
Dijklander Ziekenhuis
Hoorn, Netherlands
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Radboudumc
Nijmegen, Netherlands
Bravis Ziekenhuis
Roosendaal, Netherlands
Maasstad ZIekenhuis
Rotterdam, Netherlands
Franciscus Gasthuis & Vlietland
Schiedam, Netherlands
Haaglanden Medisch Centrum
The Hague, Netherlands
HagaZiekenhuis
The Hague, Netherlands
Elisabeth-TweeSteden Ziekenhuis
Tilburg, Netherlands
Diakonessenhuis
Utrecht, Netherlands
UMC Utrecht
Utrecht, Netherlands
St. Antonius Ziekenhuis
Utrecht & Nieuwegein, Netherlands
Streekziekenhuis Koningin Beatrix
Winterswijk, Netherlands