Clinical Research Directory

Inclusion Criteria: * 1\. Aged 50-80 years; * 2\. Permanent residents of Shiyan City; * 3\. Meet the diagnostic criteria of MCI: * 4\. Willing to cooperate in completing questionnaire survey and clinical examination, and sign informed consent; * 5\. Did not participate in other clinical trials in the past 3 months. Exclusion Criteria: * 1\. Alcohol or drug abuse; * 2\. Patients with neurological diseases that may cause cognitive dysfunction, including cerebrovascular diseases, stroke, brain tumors, Parkinson's disease, active epilepsy, etc.; * 3\. History of severe head trauma; * 4\. Severe sensory and perceptual impairment, unable to complete the cognitive function measurement; * 5\. History of mental illness such as depression, mania, anxiety, or take psychiatric drugs; * 6\. Serious heart, lung, liver, kidney dysfunction, malignant tumors, etc.; * 7\. Suffering from autoimmune diseases; * 8\. Trauma, spinal injury or any disease that may affect the motor function of the limb; * 9\. Recent infectious diseases, acute gastrointestinal diseases; * 10\. Take antibiotics, probiotics, prebiotics or biostime products within the last 1 month.