Clinical Research Directory
Browse clinical research sites, groups, and studies.
Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
Sponsor: Liverpool School of Tropical Medicine
Summary
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP). Arm 2: Intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) (IPT-SPAQ). Arm 3: Control - students will receive standard of care (no preventive treatment). Outcomes include P. falciparum infection and parasite density, anemia, cognitive function and educational testing, as well as infection prevalence and disease incidence in young children sleeping student's households to assess the impact on transmission.
Key Details
Gender
All
Age Range
6 Months - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2024-10-14
Completion Date
2026-01
Last Updated
2025-11-19
Healthy Volunteers
Yes
Conditions
Interventions
Dihydroartemisinin-Piperaquine
Treatment will be with DP (females less than 13 years old and all males) or chloroquine alone (females 13 years old or older).
Chloroquine
Treatment will be with CQ alone if female and 13 years old or older in both intervention arms.
Sulfadoxine-pyrimethamine-amodiaquine
Treatment in Arm 2 (females less than 13 years old and all males).
Locations (1)
Malaria Alert Centre
Blantyre, Malawi