Clinical Research Directory

Inclusion Criteria: * Non-cardioembolic Stroke * Acute Ischemic stroke within 7 days of symptom onset (confirmed by CT or MRI) * Age 19 and above * Significant stenosis associated with atherosclerosis in major intracranial / extracranial vessels. * National Institutes of Health Stroke Scale(NIHSS) score of 15 or less at admission * Patients with the capacity to consent for participation in the clinical trial. Exclusion Criteria: * Presence of high-risk factors for cardioembolism * Risk of ischemic stroke due to thrombosis from other causes * Patients with hemorrhagic stroke, brain tumors, or brain abscesses * Patients unable to take statins or PCSK9 inhibitors * Pre-stroke mRS score of 3 or higher * Severe liver failure (liver enzyme \> 3 times the upper normal limit) or renal failure (serum Creatinine \> 2mg/dL or estimated glomerular filtration rate \< 30 mL/min/1.73m2) * Anemia (hemoglobin \< 8mg/dL) or thrombocytopenia (platelet count \< 100K) * Uncontrolled diabetes not managed by medication or insulin * Pregnant or breastfeeding patients * Patients already receiving PCSK-9 inhibitors * Patients deemed inappropriate for participation in the clinical trial by the investigator for other reasons.