Clinical Research Directory
Browse clinical research sites, groups, and studies.
Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
Sponsor: Massachusetts General Hospital
Summary
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-02-28
Completion Date
2027-07-31
Last Updated
2025-11-03
Healthy Volunteers
No
Conditions
Interventions
Normothermic machine perfusion (NMP) of steatotic liver
Steatotic liver grafts that are selected will be run on NMP to assess quality of graft and determine whether it meets criteria for transplantation
Locations (1)
Massachusetts General Brigham
Boston, Massachusetts, United States