Clinical Research Directory

Inclusion Criteria: * Participant's nephrologist and/or primary care physician agree that participant may enroll in trial * Participants classified as pre-frail per Fried Frailty phenotype due to slowness (time taken to walk 15 feet is greater than 6 seconds) in Aim 1, OR who report 'YES' to any of the following: * "For health or physical reasons, do you have difficulty in walking a mile (5-6 blocks)?", OR * "If no, have you changed the way you walk half a mile (5-6 blocks) because of underlying health problems?", OR * "For health or physical reasons, do you have difficulty in climbing 1 flight of stairs (10 steps)?", OR * "If no, have you changed the way you climb 1 flight of stairs (10 steps) because of health problems?" Exclusion Criteria: * Myocardial infarction or unstable angina within the prior six months based on electronic medical record review or self-report * Uncontrolled cardiac arrythmia within the prior six months based on electronic medical record review or self-report * Systolic blood pressure \> 180 mm Hg and/or diastolic blood pressure \> 110 mm Hg on more than one occasion within prior six months based on electronic medical record review or self-report * Cerebrovascular event and/or transient ischemic attack within prior six months based on electronic medical record review or self-report * Abnormal cardiac stress test within the past year based on electronic medical record review or self-report * Hemoglobin of 10 g/dL or less based on electronic medical record review or self-report * Class IV heart failure based on electronic medical record review or self-report * Dyspnea and/or chest pain at rest * Dependence on wheelchair for mobility * Permanent residence in nursing home or other long-term care facility * Terminal illness or other hospice-qualifying medical condition * Planned move away from middle Tennessee within the next year * Planned major surgery in the next six months * Blindness * Concurrent enrollment in physical therapy or structured exercise program * Anticipated dialysis or kidney transplant in upcoming three months * Non-English speaking * Severe cognitive impairment based on electronic medical record review or self-report