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MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation
Sponsor: Ottawa Heart Institute Research Corporation
Summary
Cardiac allograft vasculopathy (CAV) is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. Surveillance for CAV is vital; however an ideal approach has not been established. The goal of this study is to assess whether noninvasive positron emission tomography (PET) based surveillance is non-inferior to invasive coronary angiography (ICA) surveillance.
Official title: Multiparametric Cardiac Positron Emission Tomography for Cardiac Allograft Vasculopathy Surveillance After Heart Transplantation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
576
Start Date
2024-01-08
Completion Date
2029-03
Last Updated
2025-04-03
Healthy Volunteers
No
Conditions
Interventions
ICA
Patients will undergo annual CAV surveillance with ICA
PET
Patients will undergo annual CAV surveillance with PET
Locations (5)
University of Calgary
Calgary, Alberta, Canada
Mazankowski Alberta Heart Institute
Edmonton, Alberta, Canada
University of Ottawa Heart Institute
Ottawa, Ontario, Canada
Toronto-General Hospital - University Health Network
Toronto, Ontario, Canada
Montreal Heart Institute
Montreal, Quebec, Canada